Olga Matsarskaia

Research Scientist
E-mail	matsarskaia(at)ill.eu
Office	334 - Science Building - 3rd floor
Phone	+33 (0)4 76 20 82 56
ORCID	0000-0002-7293-7287
Twitter	@olga_in_science

Responsibilities

I am a SANS staff scientist (D11, D33) and secretary of College 8.

Science

Throughout my PhD studies at the University of Tübingen (Germany, 11/2014-12/2018), I focused on the investigation of the thermodynamics underlying charge-mediated protein interactions and charge-induced phase behaviour. My main methods included small-angle scattering, complemented by electrophoretic light scattering and calorimetry.

During my post-doctoral research in the Spectroscopy Group at the ILL (06/2019-02/2020), I participated in research concerned with the dynamics of proteins in crowded conditions.

Since 02/2020, I am a SANS staff scientist at the ILL. Using the skills and knowledge I obtained so far throughout my education, my main interests consist in applying methods, principles and concepts derived from physics to biological and soft matter.

My current research involves an interdisciplinary mechanistic investigation of stimulus-responsive peptides via a collaboration with the Life Science / Deuteration Group at the ILL. Neutron scattering, particularly SANS in combination with energy-resolved methods and complementary laboratory-based techniques, offers a unique opportunity for studying these systems.

I am furthermore strongly interested in building collaborations with those studying the molecular mechanisms underlying various diseases. I am happy to contribute structural and dynamic insights into disease-related malfunctioning proteins and other macromolecules, virus assembly, drug delivery and mechanisms.

If you are interested in using neutron and/or X-ray scattering for your research, please drop me an e-mail (matsarskaia(at)ill.eu) and I will be happy to discuss your project with you!

Journal Publications

Publications

T. I. Morozova, N. A. García, O. Matsarskaia, F. Roosen-Runge, J.-L. Barrat. Structural and Dynamical Properties of Elastin-Like Peptides near their Lower Critical Solution Temperature. bioRxiv preprint (2022): https://www.biorxiv.org/content/10.1101/2022.09.25.509363v1
R. I. Randle, R. E. Ginesi, O. Matsarskaia, R. Schweins, E. Draper. Process dependent complexity in multicomponent gels. Macromol. Rapid Comm. (2022). https://doi.org/10.1002/marc.202200709
A. Santamaria, K. C. Batchu, O. Matsarskaia, S. Prévost, D. Russo, F. Natali, T. Seydel, I. Hoffmann, V. Laux, M. Haertlein, T. A. Darwish, R. A. Russell, G. Corucci, G. Fragneto, A. Maestro, N. R. Zaccai. Strikingly different roles of SARS-CoV-2 fusion peptides uncovered by neutron scattering. J. Am. Chem. Soc. 144 (2022), 2968.
A.V. Shibaev, A.I. Kuklin, V.N. Torocheshnikov, A.S. Orekhov, S. Roland, G. Miquelard-Garnier, O. Matsarskaia, I. Iliopoulos, O.E. Philippova. Double Dynamic Hydrogels Formed by Wormlike Surfactant Micelles and Cross-linked Polymer. J. Coll. Interface Sci. 611 (2021), 46.
S. Roland, G. Miquelard-Garnier, A.V. Shibaev, A.L. Aleshina, A. Chennevière, O. Matsarskaia, C. Sollogoub, O.E. Philippova, I. Iliopoulos. Dual Transient Networks of Polymer and Micellar Chains: Structure and Viscoelastic Synergy. Polymers 13 (2021), 4255.
L.J. Marshall, O. Matsarskaia, R. Schweins, D.J. Adams. Enhancement of the mechanical properties of lysine-containing peptide-based supramolecular hydrogels by chemical cross-linking. Soft Matter 17 (2021), 8459.
T. Welsh, O. Matsarskaia, R. Schweins, E. Draper. Electronic and assembly properties of a water-soluble blue naphthalene diimide. New J. Chem. 45 (2021), 14005.
M. R. Fries, N. Conzelmann, L. Günter, O. Matsarskaia, M. W. A. Skoda, R. M. J. Jacobs, F. Zhang, F. Schreiber. Bulk phase behaviour vs. interface adsorption: Specific multivalent cation and anion effects on BSA interactions. Langmuir 37 (2020), 139.
R. Maier, A. Sauter, G. Zocher, S. Da Vela, O. Matsarskaia, R. Schweins, M. Sztucki, F. Zhang, T. Stehle, F. Schreiber. Protein crystallization with a metastable liquid-liquid phase separation. Cryst. Growth Des. 20 (2020), 7951.
S. Da Vela, N. Begam, D. Dyachok, R. S. Schäufele, O. Matsarskaia, M. K. Braun, A. Girelli, A. Ragulskaya, A. Mariani, F. Zhang, F. Schreiber. Interplay between glass formation and liquid-liquid phase separation revealed by the scattering invariant. J. Phys. Chem. Lett. 11 (2020), 7273.
N. Begam, S. Da Vela, O. Matsarskaia, M. K. Braun, A. Mariani, F. Zhang, F. Schreiber. Packing and dynamics of a protein solution approaching the jammed state. Soft Matter 16 (2020), 7751.
T. Seydel, M. M. Koza, A. André, O. Matsarskaia, S. Maiti, M. Weber, R. Schweins, S. Prévost, F. Schreiber, M. Scheele. A Neutron Scattering Perspective on the Structure, Softness and Dynamics of the Ligand Shell of PbS Nanocrystals in Solution. Chem. Sci. 11 (2020), 8875.
O. Matsarskaia, F. Roosen-Runge, F. Schreiber. Multivalent ions and biomolecules: Attempting a comprehensive perspective. Chem. Phys. Chem. 21 (2020), 1742.
O. Matsarskaia, L. Bühl, C. Beck, F. Roosen-Runge, M. Grimaldo, F. Zhang, R. Schweins, T. Seydel, F. Schreiber. Evolution of structure and dynamics during thermal denaturation of proteins. Phys. Chem. Chem. Phys. 22 (2020), 18507.
N. Begam, O. Matsarskaia, M. Sztucki, F. Zhang, F. Schreiber. Unification of Lower and Upper Critical Solution Temperature Phase Behavior of Globular Protein Solutions in the Presence of Multivalent Cations. Soft Matter 16 (2020), 2128.
C. Beck, M. Grimaldo, F. Roosen-Runge, R. Maier, O. Matsarskaia, M. K. Braun, B. Sohmen, O. Czakkel, R. Schweins, F. Zhang, T. Seydel, F. Schreiber. Following protein dynamics in real-time during crystallization. Cryst. Growth. Des. 19 (2019), 7036.
O. Matsarskaia, S. Da Vela, J. Möller, A. Mariani, Z. Fu, F. Zhang, F. Schreiber. Phase separation kinetics in protein-salt mixtures with compositionally tuned interactions. J. Phys. Chem. B 123 (2019), 1913.
M. K. Braun, A. Sauter, O. Matsarskaia, M. Wolf, F. Roosen-Runge, M. Sztucki, R. Roth, F. Zhang, F. Schreiber. Reentrant phase behavior in protein solutions induced by multivalent salts: strong effect of anions Cl^- versus NO₃^-. J. Phys. Chem. B 122 (2018), 11978.
O. Matsarskaia, F. Roosen-Runge, G. Lotze, J. Möller, A. Mariani, F. Zhang, F. Schreiber. Tuning phase transitions in protein solutions by multivalent cations. Phys. Chem. Chem. Phys. 20 (2018), 27214.
M. K. Braun, M. Wolf, O. Matsarskaia, S. Da Vela, F. Roosen-Runge, R. Roth, F. Schreiber. Strong isotope effects on effective interactions and phase behavior in protein solutions in the presence of multivalent ions. J. Phys. Chem. B 121 (2017), 1731.
O. Matsarskaia, M. K. Braun, S. Da Vela, F. Zhang, F. Schreiber. Proteins as soft matter: Interactions, phase behaviour and health research. SoftComp Newsletter 14 (2017).
O. Matsarskaia, M. K. Braun, F. Roosen-Runge, M. Wolf, F. Zhang, R. Roth, F.~Schreiber. Cation-induced hydration effects cause lower critical solution temperature behavior in protein solutions. J. Phys. Chem. B 120 (2016), 7731.
M. Mülleder, K. Campbell, O. Matsarskaia, F. Eckerstorfer, M. Ralser. Saccharomyces cerevisiae single-copy plasmids for auxotrophy compensation, multiple marker selection, and for designing metabolically cooperating communities. F1000Research 5 (2016), 2351.
C. Hoppe, J. Stojanovic, Karg Foundation Young Researchers Group 2008/09 (group members: K. Geffert, M. Graner, H. M. Hennemann, J. Hessel, M. Krämer, O. Matsarskaia, L. M. Packy, M. Riederer, N. A. Schmacke, L. Schmitz-Josten, N. Schröder, D. B. Stein, C. E. Elger. Enhancing memory for lists by grouped presentation and rehearsal: a pilot study in healthy subjects with unexpected results. Seizure 18 (2009), 711.