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Publications

  • The impact of folding modes and deuteration on the atomic resolution structure of hen egg-white lysozyme. J Ramos, V Laux, M Haertlein, VT Forsyth, E Mossou, S Larsen, AE Langkilde. Acta Crystallographica D (2021, in press).
  • Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD (14/96/109). LA Perera, S Preissler, NR Zaccai, S Prévost, JM Devos, M Haertlein, & D Ron, Nature Communications 12:5004 (2021).  https://doi.org/10.1038/s41467-021-25076-7.
  • SARS-CoV-2 Spike Protein Removes Lipids From Model Membranes and Interferes with the Capacity of High Density Lipoprotein to Exchange Lipids. YY Correa, S Waldie, M Thépaut, S Micchiula, M Moulin,  F Fieschi, H Pichler, VT Forsyth, M Haertlein, M Cardenas. J. Coll. Int. Sci 602, 732-739 (2021).  https://doi.org/10.1016/j.jcis.2021.06.056
  • Evolving origin-of-transfer sequences onstaphylococcal conjugative and mobilizableplasmids––who's mimicking whom? KY Eto, SM Kwong, PT LaBreck, JE Crow,DAK Traore, N Parahitiyawa, HM Fairhurst, DS Merrell,N Firth, CS Bond, JP Ramsay. Nucleic Acids Research 49, 5177–5188 (2021).  https://doi.org/10.1093/nar/gkab303
  • Metabolic fluxes for nutritional flexibility of Mycobacterium tuberculosis. K Borah, TA Mendum, ND Hawkins, JK Ward, MH Beale, G Larrouy-Maumus, A Bhatt, M Moulin, M Haertlein, G Strohmeier, H Pichler, VT Forsyth. S Noack, CW Goulding, J McFadden, DJV Beste, Molecular Systems Biology17:e10280 (2021). https://doi.org/10.15252/msb.202110280
  • Joint neutron/X-ray crystal structure of a mechanistically relevant complex of perdeuterated urate oxidase and simulations provide insight into the hydration step of catalysis. L McGregor T FöldesS BuiM Moulin, N Coquelle, MP BlakeleyE RostaRA Steiner. IUCrJ 8, 46-59 (2021). https://doi.org/10.1107/s2052252520013615
  • Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles. F Sebastiani, MY Arteta, M Lerche, L Porcar, C Lang, RA Bragg, CS Elmore, V Krishnamurthy, RA Russell, T Darwish, H Pichler, S Waldie, M Moulin, M Haertlein, VT Forsyth, L Lindfors, M Cárdenas. ACS Nano (2021). https://doi.org/10.1021/acsnano.0c10064
  • Elongation rate and average length of amyloid fibrils in solution using isotope-labelled small-angle neutron scattering. BJ Eves, J Doutch, AE Terry, H Yin, M. Moulin, M. Haertlein, VT Forsyth, P Flagmeier, DM Dias, T Knowles, G Lotze, A Seddon, AM Squires, RSC Chem. Biology (2016). https://doi.org/10.1039/D1CB00001B
  • ApoE and ApoE Nascent-Like HDL Particles at Model Cellular Membranes: Effect of Protein Isoform and Membrane Composition. S Waldie, F. Sebastiani, M. Moulin, R Del Giudice, N Paracini, F. Rossen-Runge, Y Gerelli, S Prevost, JC Voss, TA Darwish, N Yepuri, H Pichler, S Maric, VT Forsyth, M Haertlein,M Cardenas, Front. Chem. 9: 630151 (2021). https://doi.org/10.3389/fchem.2021.630152
  • Structural insights to protein folding, stability and activity using in vivo perdeuteration of hen egg-white lysozyme. J Ramos, V Laux, M Haertlein, E Erba Boeri, KE McAuley, VT Forsyth, E Mossou, S Larsen, AE Langkilde, IUCrJ  8 (2021). https://doi.org/10.1107/S2052252521001299
  • Visualization of hydrogen atoms in a perdeuterated lectin-fucose complex reveals key details of protein-carbohydrate interactions. L Gajdos, MP Blakeley, A Kumar, M Wimmerová, M Haertlein, VT Forsyth, A Imberty, JM Devos,  Structure 29, 1–11, (2021). https://doi.org/10.1016/j.str.2021.03.003
  • A Dimerization Site at SCR-17/18 in Factor H Clarifies a New Mechanism for Complement Regulatory Control. OM Dunne, X Gao, R Nan, J Gor, PJ Adamson, DL Gordon, M Moulin, M Haertlein, VT Forsyth, SJ Perkins, Frontiers in Immunology 11, 601895 (2021). https://doi.org/10.3389/fimmu.2020.601895
  • Nanostructural deformation of high-stiffness spruce wood under tension. LH Thomas, CM Altaner, VT Forsyth, E Mossou, CJ Kennedy, A Martel, MC Jarvis. Scientific Reports 11, 453 (2021). http://dx.doi.org/10.1038/s41598-020-79676-2
  • Production of perdeuterated fucose from glyco-engineered bacteria. L Gajdos, VT Forsyth, MP Blakeley, M Haertlein, A Imberty, E Samain, JM Devos, Glycobiology 31, 151-158 (2021). https://doi.org/10.1093/glycob/cwaa059
  • Molecular Changes in Dengue Envelope Protein Domain III upon Interaction with Glycosaminoglycans. JG Hyatt, S Prevost, JM Devos, CJ Mycroft-West, MA Skidmore, A Winter, Pathogens (2020) 9, 935. http://dx.doi.org/10.3390/pathogens9110935
  • Diffusive dynamics of Aspartate α-decarboxylase (ADC) liganded with D-serine in aqueous solution. T Raskar, S Niebling, JM Devos, BA Yorke, M Härtlein, N Huse, VT Forsyth, T Seydel, AR Pearson. BioXriv doi: https://doi.org/10.1101/2020.08.11.244939
  • Visualizing the protons in a metalloenzyme electron proton transfer pathway. H Kwon, J Basran, JM Devos, R Suardíaz, MW van der Kamp, AJ Mulholland, TE Schrader, A Ostermann, MP Blakeley, PCE Moody, and EL Raven. PNAS 117 (12) 6484-6490 (2020).
  • Analytical Research Infrastructures in Europe - A key resource for the five Horizon Europe missions.  Ariese Freek,  Biegert Jens,  Borkowski Rafal Dunin, van Breukelen Martin,  Ciancio Regina,  Cicchetti Gregor,  van Daalen Mirjam,  Daillant Jean,  Dobosz Dufrénoy Sandrine, Dollinger Günther, Gleizes  Pierre-Emmanuel,  Facsko Stefan, Forsyth Trevor, Gunsenheimer Ute,  Kirkland Angus, Kolar Jana, Krell Ute, Lyonnard Sandrine,  Mitchell Ed, Pelico Primoz,  Redlich Britta, Schertler Gebhard, Schneidewind Astrid, Snoeck Etienne, Synal Hans-Arno, Velegrakis Michalis,  Wallner Anton, Wosnitza Jochen. https://zenodo.org/record/4049769#.X23I94u-lEY
  • Interdomain Flexibility within NADPH Oxidase Suggested by SANS Using LMNG Stealth Carrier. A Vermot, I Petit-Hartlein, C Breyton, A Roy, M THepaut, C Vives, M Moulin, M Hartlein, S Grudinin, SME Smith, C Ebel, A Martel, F Fieschi. Biophysical Journal.  https://doi.org/10.1016/j.bpj.2020.06.025
  • Lipoprotein ability to exchange and remove lipids from model membranes as a function of fatty acid saturation and presence of cholesterol. Sarah Waldie, Federica Sebastiani, Kathryn Browning, Selma Maric, Tania K. Lind, Nageshwar Yepuri, Tamim A. Darwish, Martine Moulin, Gernot Strohmeier, Harald Pichler, Maximilian W.A. Skoda, Armando Maestro, Michael Haertlein, V. Trevor Forsyth, Eva Bengtsson, Martin Malmsten, Marité Cárdenas. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1865 (10), (2020).  https://doi.org/10.1016/j.bbalip.2020.158769
  • Neutron scattering for structural biology. D Hoogerheide, VT Forsyth, KA Brown. Physics Today 73 (6), 36-43 (2020). https://doi.org/10.1063/PT.3.4498
  • Neutron radiobiology studies with a pure cold neutron beam. M Pedrosa-Rivera, MJ Ruiz-Magaña, I Porras, J Praena, P Torres-Sánchez, MP Sabariego, U Köster, T Forsyth, T Soldner, M Haertlein, C Ruiz-Ruiz. Nuc. Instr. Meth.  Phys. Res. B 462, 24-31 (2020)
  • Radiobiology data of melanoma cells after low-energy neutron irradiation and boron compound administration. M Pedrosa-Rivera, MJ Ruiz-Magaña, P Álvarez, I Porras, J Praena, MP Sabariego, U Köster, M Haertlein, T Forsyth, JC Ramírez, C Jover, D Jimena, JL Osorio I Postuma, C Ruiz-Ruiz. Appl. Rad. Isot. 163:109205 (2020). doi: 10.1016/j.apradiso.2020.109205
  • Thermal neutron Relative Biological Effectiveness factors for Boron Neutron Capture Therapy from In Vitro Irradiations. M Pedrosa-Rivera, J Praena, I Porras, MP Sabariego, U Köster, Ml Haertlein, VT Forsyth, JC Ramírez, C Jover, D Jimena, JL Osorio, P Álvarez, C Ruiz-Ruiz, MJ Ruiz-Magaña. Cells 9, 2144 (2020). doi:10.3390/cells9102144   
  • Polymer-Solvent Complexes and Intercalates POLYSOLVAT-12 Preface, JL Putaux, VT Forsyth, A Mader, Y Ogawa, S Prevost, R Schweins, Macromolecular Symposia 386 (1)
  • The Antifungal Mechanism of Amphotericin B Elucidated in Ergosterol and Cholesterol-Containing Membranes Using Neutron Reflectometry. R Delhom, A Nelson, V Laux, M Haertlein, W Knecht, G. Fragneto, HP Wacklin-Knecht, Nanomaterials 10, 2439 (2020). https://doi.org/10.3390/nano10122439

2019

  • Complex transitions between dihydrate and anhydrate forms of ectoine - unexpected behaviour of a highly hygroscopic compatible solute in the solid state. WM Hutzler, E Mossou, R Vollrath, M Kohagen, I El Ghrissi, M Grininger, G Zaccai, J Smiatek, D Oesterhelt,  CrystEng Comm (2019, in press). https://doi.org/10.1039/c9ce01599j
  • Molecular dynamics in cells: a neutron view.  G. Zaccai, Biochem. Biophys. Acta 1864, 129475 (2020)
  • Hierarchical nanotube self-assembly of DNA minor groove binding ligand DB921 via alkali halide triggering, R Mizuta, T Narayanan, JM Devos, M Oliva, M Grey, J Webster, W-L Ling, A Round, D Munnur, E Mossou, A Farahat, D Boykin, WD Wilson, S Neidle, R Schweins, P Rannou, M Haertlein, VT Forsyth, EP Mitchell, Macromolecular Symposia 386,1800243 (2019). https://doi.org/10.1002/masy.201800243
  • BioStruct-Africa: empowering Africa-based scientists through structural biology knowledge transfer and mentoring – recent advances and future perspectives, E Nji, DAK Traore, M Ndi, CA Jokog, DA Doyleh. Journal of Synchrotron Radiation 26, 1-8 (2019). https://doi.org/10.1107/S1600577519008981
  • Towards a molecular understanding of the water purification properties of Moringa seed proteins. M Moulin, E Mossou, L Signor, S Kieffer-Jaquinod, HM Kwaambwa, F Nermark, P Gutfreund, EP Mitchell, M Haertlein, VT Forsyth, AR Rennie, Journal of Colloid and Interface Science 554, 296-304 (2019). https://doi.org/10.1016/j.jcis.2019.06.071
  • Comparison of lipidic carrier systems for integral membrane proteins - MsbA as case study. D-M Kehlenbeck, I Josts, J Nitsche, S Busch, VT Forsyth, H Tidow. Biological Chemistry 400, 1509 (2019). https://doi.org/10.1515/hsz-2019-0171
  • In Vivo Water Dynamics in Shewanella oneidensis Bacteria at High Pressure. F Foglia, R Hazael, F Meersma, MC Wilding, V García Sakai, Sarah Rogers, LE Bove, MM Koza, M Moulin, M Haertlein, VT Forsyth, PF McMillan. Scientific Reports 9 (1), 8716 (2019). https://doi.org/10.1038/s41598-019-44704-3
  • Protein Short-Time Diffusion in a Naturally Crowded Environment, M Grimaldo, H Lopez, C Beck, F Roosen-Runge, M Moulin, JM Devos, V Laux, M Haertlein, S Da Vela, R Schweins, A Mariani, F Zgang, J-L Barray, M Oettel,  VT Forsyth, T Seydel, F Schreiber, J. Phys. Chem. Lett. 10(8),1709-1715 (2019).DOI: 10.1021/acs.jpclett.9b00345 .
  • The production of matchout-deuterated cholesterol for the study of bilayer-cholesterol interactions, S Waldie, M Moulin, L Porcar, H Pichler, GA Strohmeier, M Skoda, VT Forsyth, M Haertlein, S Maric, M Cardenas, Scientific Reports 26;9(1):5118 (2019). DOI: 10.1038/s41598-019-41439-z.
  • A molecular mechanism for transthyretin amyloidogenesis, AW Yee, M Aldeghi, MP Blakeley, A Ostermann, P Mas, M Moulin, D de Sanctis, MW Bowler, C Mueller-Dieckmann, EP Mitchell, M Haertlein, B de Groot, E Boeri Erba, VT Forsyth, Nature Communications 10, 925 (2019).  (https://doi.org/10.1038/s41467-019-08609-z). See summary.
  • Time-resolved small-angle neutron scattering as a probe for the dynamics of lipid exchange between human lipoproteins and naturally derived membranes. S Maric, T Kjellerup Lind, M Roman Raida, E Bengtsson,G Nordin Fredrikson,  S Rogers, M Moulin,M Haertlein, VT Forsyth, M Wenk, T Günther Pomorski, T Arnebrant, R Lund and M Cárdenas, Scientific Reports 9:7591 (2019).  https://doi.org/10.1038/s41598-019-43713-6

 

2018

  • Coupling of protein and hydration water dynamics in biological membranes, Wood, K., P. lazanet, M., Kessler, B., Gabel, F., Oesterhelt, D., Tobias, D., Zaccai, G. & Weik, M., (2007) Proc. Natl. Acad. Sci. USA 104, 18049-18054 [DOI pnas.0706566104].
  • NMR Crystallography: The effect of deuteration on high resolution 13C solid state NMR spectra of a 7-TM protein, K. Varga, L. Aslimovska, I.M. Parrot, M.-T. Dauvergne, M. Haertlein, V.T. Forsyth, A. Watts, Biochim. Biophys. Acta. 1768, 3029-3035 (2007). Adaptation to high temperatures through macromolecular dynamics by neutron scattering, Tehei, M., and Zaccai, G., (2007) FEBS Journal 274, 4034–4043. 
  • Shape and subunit organisation of the DNA methyltransferase M.Ahdl, Callow, P., Sukhodub, A., Taylor, J., Kneale, G., J. Mol. Biol. 69, 177-185 (2007). A methodology and an instrument for the temperature-controlled optimization of crystal growth, Budayova-Spano, M. , Dauvergne,F., Audiffren, M., Bactivelane, T., Cusack, S., (2007) Acta Cryst. D63, 339–347.
  • Neutron scattering reveals extremely slow cell water in a Dead Sea organism. M. Tehei, B. Franzetti, K. Wood, F. Gabel, E. Fabiani, M. Jasnin, M. Zamponi, D. Oesterhelt, G. Zaccai, M. Ginzburg and B.-Z. Ginzburg (2007). PNAS, 104(3), 687-1104.
  • A methodology and an instrument for the temperature-controlled optimization of crystal growth. M. Budayova-Spano, F. Dauvergne, M. Audiffren, T. Bactivelane and S. Cusack. (2007). Acta Cryst. D63, 3, 339-347.
  • The effect of deuteration on protein structure: a high-resolution comparison of hydrogenous and perdeuterated haloalkane dehalogenase. X. Liu, B. L. Hanson, P. Langan and R.E.Viola (2007). Acta Cryst. D63, 1000-1008.
  • Expression, purification, assay, and crystal structure of perdeuterated human arginase I. Di Costanzo, L., Moulin, M., Haertlein, M., Meilleur, F., Christianson, D.W (2007). Arch. Biochem. Biophys. 465(1), 82-89.
  • Adaptation to high temperatures through macromolecular dynamics by neutron scattering, Tehei, M., and Zaccai, G. (2007). FEBS Journal 274, 4034–4043.
  • Shape and subunit organisation of the DNA methyltransferase M.Ahdl, Callow, P., Sukhodub, A., Taylor, J., Kneale, G., (2007). J.Mol. Biol. 69 (1), 177-185.
  • Neutron scattering reveals extremely slow cell water in Dead Sea organisms, Tehei, M., Franzetti, B., Wood, K., Gabel, F., Fabiani, E., Jasnin, M., Zamponi, M., Oesterhelt, D., Zaccai, G., Ginzburg, M., Ginzburg, B.-Z. (2007). Proc. Nat. Acad. Sci 104 (3), 766-771.
  • Structural studies on acridine derivatives binding to telomeric DNA. Miles, S., Callow, P., Teixeira, S.C.T., Gan, Y., Denny, W., Cardin, C., Forsyth, V.T. (2006). Physica B 845, 385-386.
  • Efficient characterization of protein secondary structure in terms of screw motions, G.Kneller, P.Calligari (2006). Acta Cryst D62, 302-311.
  • A preliminary neutron diffraction study of Rasburicase, recombinant urate oxidase enzyme, complexed with 8-azaxanthin. Budayova-Spano M., Bonneté F., Ferté N., El Hajji M., Meilleur F., Blakeley M., Castro B. (2006). Acta Cryst. F62, 306-309.
  • High-Angle Neutron Fibre Diffraction in the Study of Biological systems.Forsyth, V.T., and Parrot, I.M. (2006). Neutron Scattering in Biology - Techniques and Applications, Springer Series on Biological and Medical Physics/Biomedical Engineering, Eds Fitter, J., Gutberlet, T., Katsaras, J.
  • Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II. Budayova-Spano, M., Zoe Fisher, S., Dauvergne, M.-T., Agbandje-McKenna, M., Silverman, D.N., Myles, D., McKenna, R. (2006). Acta Cryst. F62, 4-9.
  • Discovering New Classes of Brugia malayi Asparaginyl tRNA Synthetase Inhibitors and Relating Specificity to Conformational Change. S. C. K. Sukuru, T. Crepin, Y. Milev, L. C. Marsh, J. B. Hill, R. J. Anderson, J. C. Morris, A. Rohatgi, G. O'Mahony, M. Grotli, F. Danel, Y. Milev, M. G. P. Page, M. Hartlein, S. Cusack, M. A. Kron, and L. A. Kuhn. (2006). J. Comp.-Aided Mol. Design 20(3): 159-178 (DOI 10.1007/s10822-006-9043-5).
  • Brugia malayi asparaginyl-Transfer RNA synthetase Induces Chemotaxis of human leucocytes and activates G-protein-coupled receptors CXCR1 and CXCR2. Ramirez, B.L., Howard, O.M., Dong, H.F., Edamatsu, T., Gao, P., Haertlein, M., Kron, M. (2006). J. Infec. Dis. 193 (8), 1164-71.
  • X-rays and neutrons for the study of DNA structure, transitions and hydration. Parrot, I.M., Laux, V., Urban, V., Haertlein, M., Forsyth, V.T. (2006). Physica B 848, 385-386.
  • Neutrons in biology: Institut Laue - Langevin, 4-7 September 2005, Deme B, Forsyth T, Fragneto G, Hartlein M, May R, Timmins P, Zaccai G., Eur Biophys J. (2006), 35(7):549-50.
  • Production and X-ray crystallographic analysis of fully deuterated cytochrome P450cam. Meilleur F, Dauvergne MT, Schlichting I, Myles D.A. (2005). Acta Cryst. D61(5), 539-44.
  • Protonation states in human aldose reductase observed with high resolution X-ray crystallography and preliminary neutron diffraction results, Blakeley M., Hazemann, I. Mitschler, A., Meilleur, F., Dauvergne, Haertlein, M,  El-Kabbani, O., Cousido, A., van Zandt, M., Oka, M., Joachimiak, A., Petrova, T., Myles, D.A.A.,Podjarni, A.D., Chapter 2, Neutron Crystallography, 87-102, In Hydrogen- and Hydration-Sensitive Structural Biology, Eds. Nimura, N. Mizuno, H., Helliwell, J.R.and Westhof, E.
  • High-resolution neutron protein crystallography with radically small crystal volumes: application of perdeuteration to human aldose reductase. Hazemann I, Dauvergne MT,Blakeley MP, Meilleur F, Haertlein M, Van Dorsselaer A, Mitschler A, Myles D.A., Podjarny A. (2005). Acta Cryst. D61, 10, 1413-7.
  • Real time characterization of intermediates in the pathway to open complex formation by RNA polymerase. Sclavi, B., Zaychikov, E., Rogozina, A., Walther, F., Buckle, M.,Heumann, H. (2005). PNAS 102, 4706-4711.
  • Effects of soman inhibition and of structural differences on cholinesterase molecular dynamics: a neutron scattering study. Gabel, F., Weik, M., Masson, P., Renault, F., Fournier, D., Brochier, L., Doctor, B., Saxena, A., Silman, I. & Zaccai, G. (2005). Biophys J. 89(5), 3303-11.
  • Liquid-like water confined in stacks of biological membranes at 200 k and its relation to protein dynamics. Weik, M., Lehnert, U. & Zaccai, G. (2005). Biophys J., Biophys J. 89(5), 3639-46.
  • Etudes par diffraction de fibres de l’ADN double brin. Forsyth, V.T. and Parrot, I.M. (2005). Journal de Physique IV, 130, 63-74.
  • Combined X-ray and Neutron Fibre Diffraction Studies of Biological and Synthetic Polymers. Parrot, I.M., Urban, V., Gardner, K.H., Forsyth, V.T.(2005). Nucl. Instr. Meth. in Phys. Res., B238, 7-15.
  • Neutron scattering reveals the dynamic basis of protein adaptation to extreme temperature. Tehei, M., Madern, D., Franzetti, B., Zaccai, G. (2005). J Biol Chem. 9, 280(49), 40974-9.
  • A comparison of refined X-ray structures of hydrogenated and perdeuterated ray gamma E crystallin in H2O and D2O. Artero, J.B., Hartlein, M., McSweeny, S., Timmins, P.A. (2005). Acta Cryst. D61, 1541-1549.
  • Do tissue levels of autoantigenic aminoacyl-tRNA synthetase predict clinical disease? Kron, M.A., Petridis, M., Haertlein, M., Libranda-Ramirez, B., Scaffidi, L.E. (2005). Med Hypotheses, 65(6), 1124-7.
  • Aminoacyl-tRNA Synthetases and Disease in the Aminoacyl-tRNA synthetases, Kron M, Härtlein M. Landes Biosciences Publishers.  Eds: Michael Ibba, Christopher Franklyn and Stephen Cusack. (2005).
  • Water-DNA interactions by x-ray and neutron fibre diffraction. Fuller, W., Forsyth, V.T., Mahendrasingam, A. (2004). Phil. Trans. Roy. Soc. 359, 1448, 1237-1248.
  • Structural stability and dynamics of hydrogenated and perdeuterated cytochrome P450cam (CYP101). Meilleur F, Contzen J, Myles DA, Jung C. (2004). Biochemistry 13, 8744-53.
  • Expression, Localization and Alternative Function of asparaginyl-tRNA synthetase
  • in Brugia malayi.  M. Kron, M. Petridis, Y. Milev, J Leykam, M Härtlein. (2003), Molecular and Biochemical Parasitology, 129 (1), 33-39
  • Strategies for antifilarial drug development, Kron M, Kuhn L, Sanschagrin , P.C., M Härtlein, Grotli M and Cusack S. (2003), J Parasitology 89(Suppl.) S226-S235