Biology, Deuteration, Chemistry and Soft Matter support

The Biology, Deuteration, Chemistry and soft matter (BDCS) group (website under construction)
In order to maintain their ranking at an international level, European research infrastructures must optimise their resources and develop synergies at every level. The ILL is firmly committed not only to building high-performance instruments, but also to offering the best possible scientific environment for its user community. On-site sample preparation laboratories provide space and equipment to prepare and characterise samples before, during and after neutron experiments. They are available to the user community and empower in-house research. Over the years, we have established close collaborations with neighbouring institutes and launched a number of successful scientific and support partnerships, such as the Partnerships for Soft Condensed Matter (PSCM) since 2012, and for Structural Biology (PSB) since 2002. Within these partnerships, dedicated platforms and laboratories: the Deuteration (D)-Lab and Lipid (L)-Labs provide the ILL user community with a variety of deuterated biological molecules, including proteins and lipids. These activities are now grouped together in the BDCS (Biology, Deuteration, Chemistry and Soft Matter) group, headed by Frank Gabel.
Highlights







Time-resolved neutron scattering provides new insight into protein substrate processing by a AAA+ unfoldase | Atomic resolution study of a redox protein: tautomeric shifts, charge transfer and structured hydronium-water-protein networks. | Neutron anomalous scattering as a crystallographic phasing tool | Dynamics in folded and intrinsically unfolded proteins | Amyloid assembly kinetics in transthyretin using protein deuteration, mass spectrometry, crystallography | Water dynamics in intact cells of Shewanella oneidensis at high pressure | Back exchange phenomena in neutron protein crystallography and characterisation by IR spectroscopy |