Giovanna Fragneto

Structural features of interfacially adsorbed acyl-l-carnitines
Huayang Liu, Ke Fa, Xuzhi Hu, Zongyi Li, Li Zhang, Kun Ma, Giovanna Fragneto, Peixun Li, John R.P.Webster, Jordan T.Petkov, Robert K.Thomas, Jian Ren Lu
Journal of Colloid and Interface Science, 623 (2022) 368-377

Strikingly Different Roles of SARS-CoV‑2 Fusion Peptides Uncoveredby Neutron Scattering,
Andreas Santamaria, Krishna C. Batchu, Olga Matsarskaia, Sylvain F. Prévost, Daniela Russo,Francesca Natali, Tilo Seydel, Ingo Hoffmann, Valérie Laux, Michael Haertlein, Tamim A. Darwish,Robert A. Russell, Giacomo Corucci, Giovanna Fragneto, Armando Maestro, and Nathan R. Zaccai - Journal of the American Chemical Society 2022, 144(7)

New Insights into theInteraction of Class II Dihydroorotate Dehydrogenases with Ubiquinone in Lipid Bilayers as a Function of Lipid Composition. Orozco Rodriguez, J.M.;Wacklin-Knecht, H.P.; Clifton, L.A.;Bogojevic, O.; Leung, A.; Fragneto,G.; Knecht, W. Int. J. Mol. Sci. 2022, 23,2437.

Nanostructural characterization of cardiolipin-containing tethered lipid bilayers adsorbed on gold and silicon substrates for protein incorporation
Köhler S., Fragneto G., Alcaraz J.P., Nelson A., Martin D.K., Maccarini M. -Langmuir 37, 8908-8923 (2021)

Structural characterization of natural yeast phosphatidylcholine and bacterial phosphatidylglycerol lipid multilayers by neutron diffraction
Luchini A., Corucci G., Chaithanya Batchu K., Laux V., Haertlein M., Cristiglio V., Fragneto G.* -Frontiers in Chemistry 9, 628186-1-628186-11 (2021)

Lipid bilayer degradation induced by SARS-CoV-2 spike protein as revealed by neutron reflectometry
Luchini A., Micciulla S., Corucci G., Batchu K.C., Santamaria A., Laux V., Darwish T., Russell R.A., Thépaut M., Bally I., Fieschi F., Fragneto G.* -Scientific Reports 11, 14867-1-14867-11 (2021)

Insertion and activation of functional Bacteriorhodopsin in a floating bilayer
Mukhina T., Gerelli Y., Hemmerle A., Koutsioubas A., Kovalev K., Teulon J.M., Pellequer J.L., Daillant J., Charitat T., Fragneto G.* - Journal of Colloid and Interface Science 597, 370-382 (2021)

Neutron reflectometry study of the interface between two immiscible electrolyte solutions: Effects of electrolyte concentration, applied electric field, and lipid adsorption
Tummino A., Scoppola E., Fragneto G., Gutfreund P., Maestro A., Dryfe R.A.W. - Electrochimica Acta 384, 138336-1-138336-11 (2021)

Biophysical analysis of the plant-specific GIPC sphingolipids reveals multiple modes of membrane regulation
Mamode Cassim A., Navon Y., Gao Y., Decossas M., Fouillen L., Grélard A., Nagano M., Lambert O., Bahammou D., Van Delft P., Maneta-Peyret L., Simon-Plas F., Heux L., Jean B., Fragneto G., Mortimer J.C., Deleu M., Lins L., Mongrand S. - Journal of Biological Chemistry 296, 100602-1-100602-21 (2021)

Peptide discs as precursors of biologically relevant supported lipid bilayers
Luchini A., Sebastiani F., Tidemand F.G., Batchu K.C., Campana M., Fragneto G., Cárdenas M., Arleth L. - Journal of Colloid and Interface Science 585, 376-385 (2021)

The antifungal mechanism of amphotericin B elucidated in ergosterol and cholesterol-containing membranes using neutron reflectometry
Delhom R., Nelson A., Laux V., Haertlein M., Knecht W., Fragneto G., Wacklin-Knecht H.P. - Nanomaterials 10,  2439-1-2438-17 (2020)

Effect of ergosterol on the interlamellar spacing of deuterated yeast phospholipid multilayers
Luchini A., Delhom R., Cristiglio V., Knecht W., Wacklin-Knecht H., Fragneto G.* - Chemistry and Physics of Lipids 227,  104873-1-104873-7 (2020)

Behavior of hydrated lipid bilayers at cryogenic temperatures
Meineke J., Weik M., Zaccaï G., Fragneto G.* - Frontiers in Chemistry 8,  455-1-455-7 (2020)

Encapsulation of graphene in the hydrophobic core of a lipid bilayer
Arjmandi-Tash H., Lima L.M.C., Belyaeva L.A., Mukhina T., Fragneto G., Kros A., Charitat T., Schneider G.F. -Langmuir 36,  14478-14482 (2020)

Not just a fluidifying effect: Omega-3 phospholipids induce formation of non-lamellar structures in biomembranes
De Santis A., Vitiello G., Appavou M.S., Scoppola E., Fragneto G., Barnsley L.C., Clifton L.A., Ottaviani M.F., Paduano L., Russo Krauss I., D'Errico G. - Soft Matter 16,  10425-10438 (2020)

Aβ beyond the AD pathology: Exploring the structural response of membranes exposed to nascent Aβ peptide
Rondelli V., Salmona M., Colombo L., Fragneto G., Fadda G.C., Cantù L., Del Favero E. - International Journal of Molecular Sciences 21,  8295-1-8295-16 (2020)

Anesthetics significantly increase the amount of intramembrane water in lipid membranes
Himbert S., Zhang L., Alsop R.J., Cristiglio V., Fragneto G., Rheinstaedter M.C. - Soft Matter 16,  9674-9682 (2020)

Interaction with human serum proteins reveals biocompatibility of phosphocholine-functionalized SPIONs and formation of albumin-decorated nanoparticles  Russo Krauss I., Picariello A., Vitiello G., De Santis A., Koutsioubas A., Houston J.E., Fragneto G., Paduano L. - Langmuir 36,  8777-8791 (2020)

Aggregated amphiphilic antimicrobial peptides embedded in bacterial membranes Gong H., Liao M., Hu X., Fa K., Phanphak S., Ciumac D., Hollowell P., Shen K., Clifton L.A., Campana M., Webster J.R.P., Fragneto G., Waigh T.A., McBain A.J., Lu J.R. - ACS Applied Materials & Interfaces 12,  44420-44432 (2020)

The Role of Temperature and Lipid Charge on Intake/Uptake of Cationic Gold Nanoparticles into Lipid Bilayers
Lolicato, Fabio; Joly, Loic; Martinez-Seara, Hector; et al.
SMALL 2019, 15 (23) 1805046

Attractive Interaction between Fully Charged Lipid Bilayers in a Strongly Confined Geometry
Tetiana Mukhina,Arnaud Hemmerle,Valeria Rondelli,Yuri Gerelli,Giovanna Fragneto, Jean Daillant, and Thierry Charitat
J. Phys. Chem. Lett. 2019, 10, 7195−7199

Neutrons and model membranes: Moving towards complexity
Giovanna Fragneto, Robin Delhom, Loïc Joly and Ernesto Scoppola
Current Opinion in Colloid & Interface Science 2018, 38:108–121

End Point Versus Backbone Specificity Governs Characteristics of Antibody Binding to Poly(ethylene glycol) Brushes
Latza, Victoria M.; Rodriguez-Loureiro, Ignacio; Fragneto, Giovanna; Schneck, Emanuel
Langmuir 2018, 34 (46): 13946-13955

The impact of deuteration on natural and synthetic lipids: A neutron diffraction study
Luchini, Alessandra; Delhom, Robin; Deme, Bruno; …, ;G. Fragneto
Colloids and Surfaces B-Biointerfaces 2018, 168: 126-133

Directional K+ channel insertion in a single phospholipid bilayer: Neutron reflectometry and electrophysiology in the joint exploration of a model membrane functional platform
Rondelli, V.; Del Favero, E.; Brocca, P.; et al.
Biochimica et Biophysica Acta-General Subjects 2018, 1862 (8): 1742-1750

Conformation of Single and Interacting Lipopolysaccharide Surfaces Bearing O-Side Chains
Rodriguez-Loureiro, Ignacio; Latza, Victoria M.; Fragneto, Giovanna; Schneck, Emanuel
Biophysical Journal 2018, 114 (7): 1624-1635

Controlling adsorption of albumin with hyaluronan on silica surfaces and sulfonated latex particles
Berts I., Fragneto G., Porcar L., Hellsing M.S., Rennie A.R.
Journal of Colloid and Interface Science 2017, 504, 315-324

Neutron reflectometry elucidates protein adsorption from human blood serum onto PEG brushes
Latza V.M., Rodriguez-Loureiro I., Kiesel I., Halperin A., Fragneto G., Schneck E.
Langmuir 2017 33, 12708-12718

Nanoroughness strongly impacts lipid mobility in supported membranes
Blachon F., Harb F., Munteanu B., Piednoir A., Fulcrand R., Charitat T., Fragneto G., Pierre-Louis O., Tinland B., Rieu J.P.
Langmuir 2017, 33, 2444-2453

The intriguing journey of gH625-dendrimers
Falanga A., Lombardi L., Tarallo R., Franci G., Perillo E., Palomba L., Galdiero M., Pontoni D., Fragneto G., Weck M., Galdiero S.
RSC Advances 2017, 7, 9106-9114

Neutron Reflectometry reveals the interaction between functionalized SPIONs and the surface of lipid bilayers
Luchini A., Gerelli Y., Fragneto G., Nylander T., Palsson G., Appavou M., Paduano L.
Colloids and Surfaces B 2017, 151, 76-87

Membrane permeation versus amyloidogenicity: A multitechnique study of islet amyloid polypeptide interaction with model membranes
Martel A., Antony L., Gerelli Y., Porcar L., Fluitt A., Hoffmann K., Kiesel I., Vivaudou M., Fragneto G., de Pablo J.J.
Journal of the American Chemical Society 2017, 139, 137-148

The influence of mild acidity on lysyl-phosphatidylglycerol biosynthesis and lipid membrane physico-chemical properties in methicillin-resistant  Staphylococcus aureus
Rehal Reg P., Marbach H., Hubbard A.T.M., Sacranie Anam A., Sebastiani F., Fragneto G., Harvey R.D.
Chemistry and Physics of Lipids 2017, 206, 60-70

Neutron reflectometry yields distance-dependent structures of nanometric polymer brushes interacting across water
Rodriguez-Loureiro I., Scoppola E., Bertinetti L., Barbetta A., Fragneto G., Schneck E.
Soft Matter 2017, 13, 5767-5777

Nano-in-nano approach for enzyme immobilization based on block copolymers
Auriemma F., De Rosa C., Malafronte A., Di Girolamo R., Santillo C., Gerelli Y., Fragneto G., Barker R., Pavone V., Maglio O., Lombardi A.
ACS Applied Materials & Interfaces 2017, 9, 29318-29327

Influence of acyl chain saturation on the membrane-binding activity of a short antimicrobial peptide
Ciumac D., Campbell R.A., Clifton L.A., Xu H., Fragneto G., Lu J.R.
ACS Omega 2017,  2, 7482-7492                                        

Atom-scale depth localization of biologically important chemical elements in molecular layers
Emanuel Schneck, Ernesto Scoppola, Jakub Drnec, Cristian Mocuta, Roberto Felici, Dmitri Novikov, Giovanna Fragneto, and Jean Daillant 
Proc. Nat. Acad. Sci.  2016 vol. 113 no. 34, 9521–9526            

Reduction in Tension and Stiffening of Lipid Membranes in an Electric Field Revealed by X-Ray Scattering
Arnaud Hemmerle, Giovanna Fragneto, Jean Daillant, and Thierry Charitat
Phys. Rev. Lett. 2016, 116, 22810

Amyloidβ Peptides in interaction with raft-mime model membranes: a neutron reflectivity insight
Valeria Rondelli, Paola Brocca, Simona Motta, Massimo Messa, Laura Colombo, Mario Salmona, Giovanna Fragneto, Laura Cantù & Elena Del Favero
Scientific Reports 6, 20997

The component group structure of DPPC bilayers obtained by specular neutron reflectometry.
Belicka M; Gerelli Y; Kucerka N; Fragneto G.
Soft Matter 2015, 11(31): 6275-83

Nucleolipid bilayers: A quartz crystal microbalance and neutron    reflectometry study
Montis, Costanza    Gerelli, Yuri    Fragneto, Giovanna    Nylander, Tommy    Baglioni, Piero    Berti, Debora
COLLOIDS AND SURFACES B-BIOINTERFACES 2016, 137, 203-213

Lipid polyunsaturation determines the extent of membrane structural changes induced by Amphotericin B in Pichia pastoris yeast
de Ghellinck, Alexis    Fragneto, Giovanna    Laux, Valerie    Haertlein, Michael    Jouhet, Juliette    Sferrazza, Michele    Wacklin, Hanna
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 2015, 1848 (10)  2317 – 2325

Neutron reflectometry from poly (ethylene-glycol) brushes binding anti-PEG antibodies: Evidence of ternary adsorption.
Emanuel Schneck, Ida Berts, Avraham Halperin, Jean Daillant, Giovanna Fragneto
Biomaterials 04/2015; 46. DOI:10.1016/j.biomaterials.2014.12.041

Generic Role of Polymer Supports in the Fine Adjustment of Interfacial Interactions between Solid Substrates and Model Cell Membranes

Fernanda F Rossetti, Emanuel Schneck, Giovanna Fragneto, Oleg V Konovalov, Motomu Tanaka
Langmuir 03/2015; 31(15). DOI:10.1021/la504253p

Fusion of raft-like lipid bilayers operated by a membranotropic domain of the HSV-type I glycoprotein gH occurs through a cholesterol-dependent mechanism
Giuseppe Vitiello, Annarita Falanga, Ariel Alcides Petruk, Antonello Merlino, Giovanna Fragneto, Luigi Paduano, Stefania Galdiero, Gerardino D'Errico Soft Matter 02/2015; DOI:10.1039/C4SM02769H

Multi-lamellar organization of fully deuterated lipid extracts of yeast membranes
Y. Gerelli, A. de Ghellinck, J. Jouhet, V. Laux, M. Haertlein, G. Fragneto
Acta Crystallographica Section D Biological Crystallography 12/2014; 70(12):3167

Étudier la structure des membranes biologiques : l’intérêt des systèmes modèles et des neutrons
Giovanna Fragneto
Reflets de la physique 11/2014; 41:36.

Structure and Stability of Phospholipid Bilayers Hydrated by a Room Temperature Ionic Liquid / Water Solution: A Neutron Reflectometry Study.
Antonio Benedetto, Frank Heinrich, Miguel Angel Gonzalez, Giovanna Fragneto, Erik B Watkins, Pietro Ballone
The journal of physical chemistry. B. 09/2014

Interaction of amphotericin B with lipid monolayers.
Fabrizia Foglia, Giovanna Fragneto, Luke Ashley Clifton, M Jayne Lawrence, David J Barlow
Langmuir 07/2014

Polymeric Smart Coating Strategy for Titanium Implants
Ida Berts, Dmitri Ossipov, Giovanna Fragneto, Andreas Frisk, Adrian R. Rennie
Advanced Engineering Materials 03/2014

A lipophilic "fully-anti" dodecamer from (5'S)-5',8-cyclo-2'-deoxyguanosine
Silvia Peraccini, Michael A. Terzidis, Enrico J. Baldassarri, Giovanna Fragneto, Paolo Mariani, Stefano Masiero, Chryssostomos Chatgilialoglu
Chemical Communications 01/2014

Production and Analysis of Perdeuterated Lipids from Pichia pastoris Cells.
Alexis de Ghellinck, Hubert Schaller, Valérie Laux, Michael Haertlein, Michele Sferrazza, Eric Maréchal, Hanna Wacklin, Juliette Jouhet, Giovanna Fragneto
PLoS ONE 01/2014; 9(4):e92999

Neutron Reflectometry Elucidates Density Profiles of Deuterated Proteins Adsorbed onto Surfaces Displaying Poly(ethylene glycol) Brushes: Evidence for Primary Adsorption.
Schneck, Emanuel; Schollier, Audrey; Halperin, Avraham; et al.
Langmuir : the ACS journal of surfaces and colloids  Volume: 29   Issue: 46   Pages: 14178-87   Published: 2013

Lipid Exchange and Flip-Flop in Solid Supported Bilayers
Gerelli, Yuri; Porcar, Lionel; Lombardi, Lucia; et al.
LANGMUIR  Volume: 29   Issue: 41   Pages: 12762-12769   Published: OCT 15 2013

Editorial on the Topical Issue "Neutron Biological Physics"
Fragneto, Giovanna; Gabel, Frank
EUROPEAN PHYSICAL JOURNAL E  Volume: 36   Issue: 7     Article Number: 81   Published: JUL 2013

A neutron reflection study of adsorbed deuterated myoglobin layers on hydrophobic surfaces
Brouette, Nicolas; Fragneto, Giovanna; Cousin, Fabrice; et al.
JOURNAL OF COLLOID AND INTERFACE SCIENCE  Volume: 390   Pages: 114-120   Published: JAN 15 2013

Adsorption of α-synuclein to supported lipid bilayers - positioning and role of electrostatics.
Erik Hellstrand, Marie Grey, Marie-Louise Ainalem, John F Ankner, V Trevor Forsyth, Giovanna Fragneto, Michael Haertlein, Marie-Therese Dauvergne, Hanna Nilsson, Patrik Brundin, Sara Snogerup Linse, Tommy Nylander, Emma Sparr

Tuning the density profile of surface-grafted hyaluronan and the effect of counter-ions.
Berts, Ida; Fragneto, Giovanna; Hilborn, Jons; et al.
The European physical journal. E, Soft matter  Volume: 36   Issue: 7   Pages: 9884   DOI: 10.1140/epje/i2013-13070-7   Published: 2013-Jul (Epub 2013 Jul 16)

Neutrons for rafts, rafts for neutrons.
Rondelli, V; Del Favero, E; Motta, S; et al.
The European physical journal. E, Soft matter  Volume: 36   Issue: 7   Pages: 9888   DOI: 10.1140/epje/i2013-13073-4   Published: 2013-Jul (Epub 2013 Jul 16)

Calcium mediated interaction of calf-thymus DNA with monolayers of distearoylphosphatidylcholine: a neutron and X-ray reflectivity study (pdf - 0.91 Mi)
Aleksandra P Dabkowska, Jonathan P Talbot, Leide Cavalcanti, John R P Webster, Andrew Nelson, David J Barlow, Giovanna Fragneto, Jayne Lawrence
Soft Matter 2013

Cholesterol modulates the fusogenic activity of a membranotropic domain of the FIV glycoprotein gp36 (pdf - 1.17 Mi)
Giuseppe Vitiello, Giovanna Fragneto, Ariel Alcides Petruk, Annarita Falanga, Stefania Galdiero, Anna Maria D 'ursi, Antonello Merlino, Gerardino D Errico
Soft Matter 2013

Effect of functionalized gold nanoparticles on floating lipid bilayers (pdf - 1.11 Mi)
Sabina Tatur, Marco Maccarini, Robert David Barker, Andrew Nelson, Giovanna Fragneto
LANGMUIR  Volume: 29   Issue: 22   Pages: 6606-6614   DOI: 10.1021/la401074y   Published: JUN 4 2013

Membrane insertion of sliding anchored polymer (pdf - 0.97 Mi)
Martin Bauer, Max Bernhardt, Thierry Charitat, Patrick Kekicheff, Christophe Fajolles, Giovanna Fragneto, Carlos M. Marques, Jean Daillant
Soft Matter 2013

Neutron reflectivity of supported membranes incorporating terminally anchored polymers: Protrusions vs. blisters (pdf - 382 Ki)
G. Fragneto, A. Halperin, B. Klösgen and M. Sferrazza
Eur. Phys. J. E (2013) 36: 3

Competition for space between a protein and lipid monolayers (pdf - 1.48 Mi)
Giovanna Fragneto, Stéphane Alexandre, Jean-Marc Valleton, Francis Rondelez
Colloids and Surfaces B: Biointerfaces 103 (2013) 416– 421

Membrane thickness and the mechanism of action of the short peptaibol trichogin GA IV (pdf - 2.14 Mi)
S Bobone, Y Gerelli, M De Zotti, G Bocchinfuso, A Farrotti, B Orioni, F Sebastiani, E Latter, J Penfold, R Senesi, F Formaggio, A Palleschi, C Toniolo, G Fragneto, L Stella
Biochimica et Biophysica acta. 03/2013; 1828(3):1013 - 1024

Neutrons and model membranes (Review) (pdf - 669 Ki)
G Fragneto
The European Physical Journal Special Topics. 03/2012; 213:327-342

Diffraction studies on natural and model lipid bilayers (pdf - 387 Ki)
F Sebastiani, R Harvey, S Khanniche, J.-B Artero, M Haertlein, G Fragneto
The European Physical Journal Special Topics. 12/2012; 213:355-365

Protein adsorption properties of OEG monolayers and dense PNIPAM brushes probed by neutron reflectivity (pdf - 477 Ki)
N Brouette, C Xue, M Haertlein, M Moulin, G Fragneto, D E Leckband, A Halperin, M Sferrazza
The European Physical Journal Special Topics. 01/2012; 213(1):343-353.

Controlling interactions in supported bilayers from weak electrostatic repulsion to high osmotic pressure (pdf - 763 Ki)
Arnaud Hemmerle, Linda Malaquin,Thierry Charitat, Sigolène Lecuyer, Giovanna Fragneto and Jean Daillant
PNAS 2012 ; published ahead of print November 19, 2012, doi:10.1073/pnas.1211669109

Lipid Rearrangement in DSPC/DMPC Bilayers: A Neutron Reflectometry Study (pdf - 1.12 Mi)
Yuri Gerelli, Lionel Porcar, and Giovanna Fragneto
Langmuir, 2012, 28 (45), pp 15922–15928

A neutron reflection study of adsorbed deuterated myoglobin layers on hydrophobic surfaces (pdf - 496 Ki)
Nicolas Brouette, Giovanna Fragneto, Fabrice Cousin, Martine Moulin, Michael Haertlein, Michele Sferrazza
Journal of Colloid and Interface Science, Volume 390, Issue 1, 15 January 2013, Pages 114-120

Neutron diffraction studies of the interaction between amphotericin B and lipid-sterol model membranes (pdf - 526 Ki)
Fabrizia Foglia, M. Jayne Lawrence, Bruno Deme, Giovanna Fragneto and David Barlow
Nature SCIENTIFIC REPORTS (2012) | 2 : 778 | DOI: 10.1038/srep00778

Ganglioside GM1 forces the redistribution of cholesterol in a biomimetic membrane (pdf - 777 Ki)
V. Rondelli, G. Fragneto , S. Motta, E. Del Favero, P. Brocca, S. Sonnino, L. Cantù
Biochimica et Biophysica Acta 1818 (2012) 2860–2867

Floating lipid bilayers: models for physics and biology (pdf - 1.84 Mi)
Giovanna Fragneto, Thierry Charitat and Jean Daillant
EBJO 2012 10.1007/s00249-012-0834-4

Co-existence of gel and fluid lipid domains in single-component phospholipid membranes (pdf - 631 Ki)
C. L. Armstrong, M. A. Barrett, L. Toppozini, N. Kucerka, Z. Yamani, J. Katsaras, G. Fragneto and M. C. Rheinstädter
Soft Matter, 2012, 8, 4687

Destabilization of Lipid Membranes by a Peptide Derived from Glycoprotein gp36 of Feline Immunodeficiency Virus: A Combined Molecular Dynamics/Experimental Study (pdf - 3.08 Mi)
A. Merlino, G. Vitiello, M. Grimaldi, F. Sica, E. Busi, R. Basosi, A. M. D’Ursi, G. Fragneto, L. Paduano, and G. D’Errico
J. Phys. Chem. B, 2012, 116 (1), pp 401–412

Insertion properties of cholesteryl cyclodextrins in phospholipid membranes: a molecular study (pdf - 1.54 Mi)
Martin Bauer, Thierry Charitat, Christophe Fajolles, Giovanna Fragneto and Jean Daillant
Soft Matter, 2012, 8, 942

Reflectivity from floating bilayers: can we keep the structural asymmetry? (pdf - 533 Ki)
Rondelli V, Fragneto G, Motta S, Del Favero E, Cantù L (2012)
Journal of Physics: Conference Series 340:012083

Co-adsorption of beta-casein and calcium phosphate nanoclusters (CPN) at hydrophilic and hydrophobic solidesolution interfaces studied by neutron re!ectometry (pdf - 770 Ki)
David Follows, Carl Holt, Robert K. Thomas, Fredrik Tiberg, Giovanna Fragneto, Tommy Nylander
Foof Hydrocolloiids (2011) 25:44, 724-733

A neutron diffraction study of purple membranes under pressure (pdf - 1.36 Mi) 
Rossand, IG; Zaccai, G; Fragneto, G
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010) 66, 1232-1236

Destruction and Solubilization of Supported Phospholipid Bilayers on Silica by the Biosurfactant Surfactin (pdf - 2.46 Mi)
Hsin-Hui Shen, Robert K. Thomas, Jeffrey Penfold, and Giovanna Fragneto
Langmuir 2010, 26(10), 7334–7342

Deciphering Membrane Insertion of the Diphtheria Toxin T Domain by Specular Neutron Reflectometry and Solid-State NMR Spectroscopy (pdf - 759 Ki) 
A. Chenal, L. Prongidi-Fix, A. Perier, C. Aisenbrey, G. Vernier, S. Lambotte, M. Haertlein, Dauvergne M.-T., G. Fragneto, B. Bechinger, D. Gillet, V. Forge and M. Ferrand
J. Mol. Biol. (2009) 391, 872–883

Biological Physics near Surfaces/Interfaces: a Perspective (pdf - 342 Ki)
G. Fragneto
Eur. Phys. J. E., 2009, 30 (2), p 239

Hydrated cholesterol: Phospholipid domains probed by synchrotron radiation (pdf - 811 Ki)
I. Solomonov, J. Daillant, G. Fragneto, K. Kjaer, J. S. Micha, F. Rieutord and L. Leiserowitz
Eur. Phys. J. E., 2009, 30 (2), p 215

Fibronectin adsorption studied using neutron reflectometry and complementary techniques (pdf - 519 Ki)
M. Al-Jawad, G. Fragneto, J. Liu, S. R. Chang and B. Clarkso
Eur. Phys. J. E., 2009, 30 (2), p 175

Interaction of Cationic Lipoplexes with Floating Bilayers at the Solid−Liquid Interface (pdf - 2.49 Mi)
Jonathan P. Talbot, David J. Barlow, M. Jayne Lawrence, Peter A. Timmins and Giovanna Fragneto
Langmuir, 2009, 25 (7), pp 4168–4180

Interaction of Cationic Lipid/DNA Complexes with Model Membranes As Determined by Neutron Reflectivity (pdf - 695 Ki)
P. Callow, G. Fragneto, R. Cubitt, D. J. Barlow and M. J. Lawrence
Langmuir, 2009, 25 (7), pp 4181–4189

Specular Neutron Reflectivity Studies of the Interaction of Cytochrome c with Supported Phosphatidylcholine Bilayers Doped with Phosphotidylserine (pdf - 370 Ki)
A. P. Dabkowska, G. Fragneto, A. V. Hughes, P. J. Quinn and M. J. Lawrence
Langmuir, 2009, 25 (7), pp 4203–4210

Lamellar Stacking Split by In-Membrane Clustering of Bulky Glycolipids (pdf - 846 Ki)
E. Del Favero, A. Raudino, P. Brocca, S. Motta, G. Fragneto, M. Corti and L. Cantú
Langmuir, 2009, pp 4190–4197fileadmin/users_files/media/groups/LSS/doc/Giovanna_FRAGNETO/publications/steichen_langmuir_2009.pdf

Interfacial Behavior of a Hairpin DNA Probe Immobilized on Gold Surfaces (pdf - 408 Ki)
M. Steichen, N. Brouette, C. Buess-Herman, G. Fragneto and M. Sferrazza
Langmuir, 2009, pp 4162–4167

Fluctuations and destabilization of single phospholipid bilayers (pdf - 1.59 Mi)
Charitat T., Lecuyer S. and G. Fragneto
Biointerphase, 2008, 3(2), 3-15

Adsorption of cubic liquid crystalline nanoparticles on model membranes (pdf - 597 Ki)
Vandoolaeghe P., Rennie A.R., Campbell R.A., Thomas R.K., Höök F., Fragneto G., Tiberg F., Nylander T.
Soft Matter 4, 2267-2277 (2008)

Orientation-selective incorporation of transmembrane F0F1 ATP synthase complex from Micrococcus luteus in polymer-supported membranes (pdf - 877 Ki)
Tutus M., Rossetti F.F., Schneck E., Fragneto G., Förster F., Richter R., Nawroth T., Tanaka M.
Macromolecular Bioscience 8, 1034-1043 (2008)

Structural and Dynamical Studies from Biomimetic Systems: an Overview
G. Fragneto and M. Rheinstadter
C.R. Physique, 2007, 8, 865-883

Primary versus Ternary Adsorption of Proteins onto PEG Brushes (pdf - 571 Ki)
A. Halperin, G. Fragneto, A. Schollier and M. Sferrazza
Langmuir, 2007, (23) 10603 - 10617     

Distribution of reaction products in phospholipase A2 hydrolysis (pdf - 815 Ki)
H. P. Wacklin, F. Tiberg, G. Fragneto, R. K.Thomas
BBA Biomembranes, 2007, (1768) 1036 - 1049

Structure and Stability of DPPE planar bilayers (pdf - 275 Ki)
Barry Stidder, Giovanna Fragneto and Stephen J. Roser
Soft Matter, 2007, 3 (2) pp 214 - 222

Human saliva forms a complex film structure on alumina surfaces (pdf - 372 Ki)
M. Cardenas, T. Arnebrant, A. R. Rennie, G. Fragneto, R. K. Thomas and L. Lindh
Biomacromolecules, 2007, 8, pp.65-69

In-situ and neutron diffraction study of lipid membrane swelling (pdf - 335 Ki)
L.P. Cavalcanti,H. Haas, H.N. Bordallo, O. Konovalov, T. Gutberlet, G. Fragneto
Eur. Phys. J. special Topics, 2007, 141, pp.217-221

Effect of an electric field on a floating lipid bilayer: A neutron reflectivity study (pdf - 566 Ki)
S. Lecuyer, G. Fragneto, and T. Charitat
Eur. Phys. J. E, 2006, 21 pp. 153-159;    

Effect of Low Amounts of Cholesterol on the Swelling Behavior of Floating Bilayers (pdf - 191 Ki)
Barry Stidder, Giovanna Fragneto, and Stephen J. Roser
Langmuir, 2005, 21 (20) 9187 - 9193;  

Cholesterol Induced Suppression of Large Swelling of Water Layer in Phosphocholine Floating Bilayers (pdf - 296 Ki)
Barry Stidder, Giovanna Fragneto, Robert Cubitt, Arwel V. Hughes, and Stephen J. Roser
Langmuir, 2005, 21 (19) pp 8703 - 8710     

Structure and fluctuations of a single floating lipid bilayer (pdf - 421 Ki)
J. Daillant, E. Bellet-Amalric, A. Braslau, T. Charitat, G. Fragneto, F. Graner, S. Mora, F. Rieutord and B. Stidder
Proc. Nat. Acad. Sci., 2005, 102 (33): 11639 

Interaction of Cationic Lipid Vesicles with Model Cell Membranes As Determined by Neutron Reflectivity (pdf - 226 Ki)
P. Callow, G. Fragneto, R. Cubitt, D. J. Barlow, M. J. Lawrence, and P. Timmins
Langmuir, 2005; 21(17); 7912-7920   

SANS investigations of the lipidic cubic phase behaviour in course of bacteriorhodopsin crystallization (pdf - 237 Ki)
R. Efremov, G. Shiryaeva, G. Bueldt, A. Islamov, A. Kuklin, L. Yaguzhinsky, G. Fragneto-Cusani and V. Gordeliy
Journal of Crystal Growth Vol 275, Issues 1-2 , 15 Feb 2005, Pages e1453-e1459 

Composition of Supported Model Membranes Determined by Neutron Reflection (pdf - 229 Ki)
Vacklin H. P., Tiberg F., Fragneto, G., Thomas, R. K.
Langmuir 2005; 21(7); 2827-2837    

Phospholipase A2 Hydrolysis of Supported Phospholipid Bilayers: A Neutron Reflectivity and Ellipsometry Study (pdf - 249 Ki)
Vacklin H. P., Tiberg, F., Fragneto, G., Thomas, R. K.
Biochemistry 2005, 44(8), 2811-2821.

Structural Studies of the Neural-Cell-Adhesion Molecule by X-ray and Neutron Reflectivity (pdf - 224 Ki)
C. P. Johnson, G. Fragneto, O. Konovalov, V. Dubosclard, J.-F. Legrand and D. E. Leckband
Biochemistry, 2005,  44(2), 546-554  

Distorted Hexagonal Phase Studied by Neutron Diffraction: Lipid Components Demixed in a Bent Monolayer (pdf - 720 Ki)
L. Ding, T. M. Weiss, G. Fragneto, W. Liu, L. Yang and H. W. Huang
Langmuir 2005, 21, 203-210    

X-ray and neutron reflectivity study of solid-supported lipid membranes prepared by spin coating (pdf - 112 Ki)
J. Generosi, C. Castellano, D. Pozzi, A. Congiu Castellano, R. Felici, F. Natali, G. Fragneto
Journal of Applied Physics 2004, 96, 6839-6844     

Collective dynamics of lipid membranes studied by inelastic neutron scattering (pdf - 0.97 Mi)
Rheinstadter M. C., Ollinger C., Fragneto G., F. Demmel and Salditt T., Physical Review Letters, 93 (10), 108107, 2004 

Collective dynamics in phospholipid bilayers investigated by inelastic neutron scattering: exploring the dynamics of biological membranes with neutrons (pdf - 844 Ki)
Rheinstadter M. C., Ollinger C ., Fragneto G. and Salditt T., Physica B, 350, 136- 139,2004

Phospholipid bilayer formation at a bare Si-surface. A time-resolved neutron reflectivity study
Gutberlet T., Steitz R., Fragneto G. and Kloesgen B., Journal of Physics: Condensed Matter, 16 (26), S2469- S2476,2004    

On How Reflectivity Studies Can Help in Understanding Interactions at Cell Surfaces
Fragneto-Cusani G. in Self-Assembly, Ed. B. H. Robinson, IOS Press, The Netherlands, 2003, pp. 63-69

Swelling of phospholipid floating bilayers: The effect of chain length (pdf - 152 Ki)
Fragneto G., Charitat T., Bellet-Amalric E., Cubitt R., Graner F. - Langmuir Vol. 19 pp. 7695-7702, 2003 

Thermal fluctuations of oriented lipid membranes by nonspecular neutron reflectometry (pdf - 446 Ki)
Salditt T., Muenster C., Mennicke U., Ollinger C.,Fragneto G. - Langmuir Vol. 19 pp. 7703-7711, 2003 

Neutron and X-ray studies of lipid bilayers
Fragneto G., Bellet-Amalric E., Graner F. -  In : HEITZ F.Membrane Interacting Peptides and Proteins 81-7736-104-X Research Signpost, 2002  

Membranes at interfaces: Structure studies by AFM and time-resolved neutron reflectivity
Kloesgen B., Spangenberg T., Niehus H., Gutberlet T., Steitz R., Fragneto G. - Cellular and Molecular Biology Letters Vol. 7 pp. 240, 2002

Dewetting of solid-supported multilamellar lipid layers (pdf - 262 Ki)
Perino-Gallice L., Fragneto G., Mennicke U., Salditt T., Rieutord F. European Physical Journal E Vol. 8 pp. 275-282, 2002   

A fluid floating bilayer (pdf - 466 Ki)
Fragneto G., Charitat T., Graner F., Mecke K., Perino-Gallice L., Bellet-Amalric E. -  Europhysics Letters Vol. 53 pp. 100-106, 2001

Neutron reflectivity at the solid/liquid interface: Examples of applications in biophysics (pdf - 720 Ki)
Fragneto-Cusani G. - Journal of Physics Condensed Matter Vol. 13 pp. 4973-4989, 2001

Neutron and X-ray reflectivity studies at solid-liquid interfaces: The interaction of a peptide with model membranes
Fragneto G., Bellet-Amalric E., Charitat T., Dubos P., Graner F., Perino-Gallice L.,, Physica B Vol. 276-278 pp. 501-502, 2000   

Interaction of the third helix of antennapedia homeodomain with a deposited phospholipid bilayer: (pdf - 220 Ki)
A neutron reflectivity structural study
Fragneto G., Graner F., Charitat T., Dubos P., Bellet-Amalric E. - Langmuir Vol. 16 pp. 4581-4588, 2000 

Adsorption of proteins from aqueous solutions on hydrophobic surfaces studied by neutron reflection (pdf - 182 Ki)
Fragneto G., Su T.J., Lu J.R., Thomas R.K., Rennie A.R. - Physical Chemistry - Chemical Physics Vol. 2 pp. 5214-5221, 2000

Biology at ECNS'99
Fragneto-Cusani G. - Neutron News Vol. 11 pp. 12-13, 2000 

Adsorbed and free lipid bilayers at the solid-liquid interface viewed by specular and off-specular reflectivity
Perino-Gallice L., Bellet-Amalric E., Braslau A., Charitat T., Daillant J., Fragneto G., Graner F. -Progress in Colloid and Polymer Science Vol. 115 pp. 171-173, 2000

Adsorbed and free lipid bilayers at the solid-liquid interface (pdf - 417 Ki)
Charitat T., Bellet-Amalric E.,Fragneto G., Graner F. -   European Physical Journal B Vol. 8 pp. 583-593, 1999     

Neutron Reflection Study of Bovine b-Casein Adsorbed on OTS Self-Assembled Monolayers (pdf - 1.04 Mi)

Neutron reflectivity measurements at the oil/water interface for the study of stimuli-responsive emulsions
Protat, M.; Bodin-Thomazo, N.; Malloggi, F.; et al.
European Physical Journal E   Volume: 41   Issue: 7     Article Number: 85   Published: JUL 16 2018

Solvent Extraction: Structure of the Liquid–Liquid Interface Containing a Diamide Ligand
Ernesto Scoppola, Erik B. Watkins, Richard A. Campbell, Oleg Konovalov, Luc Girard, Jean-Francois Dufreche, Geoffroy Ferru, Giovanna Fragneto, and Olivier Diat
Angew. Chem. Int. Ed. 2016, 55, 9326 –9330   

Structure of Liquid/Liquid interface during Solvent Extraction combining X-ray and Neutron reflectivity 
Ernesto Scoppola, Erik watkins,  Lionel Porcar, Richard Campbell, Oleg Konovalov, Giovanni Li Destri, Giovanna Fragneto, Olivier Diat 
Physical Chemistry Chemical Physics 05/2015; DOI:10.1039/C5CP01809A 

Light-emitting dendrimer film morphology: A neutron reflectivity study (pdf - 224 Ki)
S. V. Vickers, H. Barcena, K. A. Knights, R. K. Thomas, J.-C. Ribierre, S. Gambino, I. D. W. Samuel, P. L. Burn, and Giovanna Fragneto
Appl. Phys. Lett. 96, 263302 (2010); doi:10.1063/1.3457438

The H-sorption behaviour of ball-milled MgH2 5 MOL.% FeF3 studied by in-situ small angle neutron scattering (pdf - 254 Ki)
Deledda S., Vennström M., Borissova A., Yavari A.R., Fragneto G. 
Reviews on Advanced Materials Science 18, 616-620 (2008)

Neutron reflectivity study of the kinetics of polymer-polymer interface formation (pdf - 171 Ki)
W. Béziel, G. Fragneto, F. Cousin and M. Sferrazza
PHYSICAL REVIEW E 2008, 78, 022801

In situ neutron diffraction analysis of the influence of geometric confinement on crystalline swelling of montmorillonite
Devineau K, Bihannic I, Michot L, Villieras F, Masrouri F, Cuisinier O, Fragneto G., Michau N
Appl. Clay Sci.  2006, 31 (1-2): 76-84

Hydration of a synthetic clay with tetrahedral charges: A multidisciplinary experimental and numerical study
Rinnert E, Carteret C, Humbert B, Fragneto-Cusani G, Ramsay JDF, Delville A, Robert JL, Bihannic I, Pelletier M, Michot LJ
J. Phys. Chem. B 2005, 109 (49): 23745-23759

Locating Counterions in Guanosine Quadruplexes: A Contrast-Variation Neutron Diffraction Experiment in Condensed Hexagonal Phase
Federiconi F., Ausili P., Fragneto G., Ferrero C., and Mariani P.
J. Phys. Chem. B 2005, 109, 11037-11045

Relating the physical structure and optical properties of conjugated polymers using neutron reflectivity in combination with photoluminescence spectroscopy 
Mitchell WJ, Burn PL, Thomas RK, Fragneto G. et al. 
J. Appl. Phys. 95 (5): 2391-2396 MAR 1 2004

Probing the polymer-electrode interface using neutron reflection 
Mitchell W.J., Burn P.L., Thomas R.K., Fragneto G. 
Appl. Phys. Lett. - Vol. 82 pp. 2724-2726, 2003

Neutron reflection study on soluble and insoluble poly[2-(2'-ethylhexyloxy)-5-methoxy-1,4- phenylenevinylene) films
Webster G.R., Mitchell W.J., Burn P.L., Thomas R.K., Fragneto G., Markham J.P.J., Samuel I.D.W.
J. of Appl. Phys. Vol. 91 pp. 9066-9071, 2002

Interlayer structure of a clay-polymer-salt-water system 
Swenson J., Smalley M.V., Hatharasinghe H.L.M., Fragneto G.
Langmuir Vol. 17 pp. 3813-3818, 2001

Neutron Reflectivity Studies Of Aerosol-OT Monolayers Adsorbed At The  Oil/Water, Air/Water And Hydrophobic Solid/Water Interfaces 
Li Z. X., Lu J. R., Fragneto G., Thomas R. K.,Binks, B.P., Fletcher P.D.I., Penfold J. 
J. Coll. Surf. A, 1998, 135:1-3, pp. 277-281.

Neutron Reflection from Mixtures of Sodium Dodecyl Sulphate and Dodecyl Betaine  Adsorbed at the Hydrophobic Solid/Aqueous Interface 
Hines J.D., Fragneto G., Thomas R.K., Garrett P.R., Rennie G., Rennie A.R. 
J. Coll. Int. Sci., 1997, Vol. 189, pp. 259-267

Structure of Monolayers of Tetraethylene Glycol Monododecyl Ether Adsorbed on Self-Assembled Monolayers on Silicon - A Neutron Reflectivity Study 
Fragneto G., Lu J. R., Mcdermott D. C., Thomas R. K., Rennie A. R., Gallagher P. D., Satija S. K
Langmuir, 1996, Vol.12, No.2, pp.477-486

A Neutron Reflectivity Study of The Adsorption of Aerosol-OT on Self-Assembled Monolayers on Silicon 
Fragneto G., Li Z. X., Thomas R. K., Rennie A. R., Penfold J. 
J. Coll. Int. Sci., 1996, Vol.178, No.2, pp.531-537

Neutron Reflection from Hexadecyl Trimethyl Ammonium Bromide Adsorbed on Smooth and Rough Silicon Surfaces 
Fragneto G., Thomas R. K., Rennie A. R., Penfold J. 
Langmuir, 1996, Vol.12, No.25, pp 6036-6043

The Effect of Shear on the Adsorption of Non-Ionic Surfactants at the Liquid-Solid Interface
Penfold J., Staples E., Tucker I., Fragnetto G. 
Physica B, 1996, Vol.221, pp 325-330.

Variation of Surfactant Counterion and its Effect on the Structure and Properties of Aerosol-OT Based Water-In-Oil Microemulsions 
Eastoe J., Fragneto G., Robinson B. H., Towey T. F., Heenan R. K., Leng F. 
J.Chem. Soc. Far. Trans., 1992, Vol.88, No.3, pp.461-471

Small-Angle Neutron Scattering from Novel Bis-2- Ethylhexylsulphosuccinate Microemulsions Evidence for Nonspherical Structures
Eastoe J., Fragneto G., Steytler D. C., Robinson B. H., Heenan R. K. 
Physica B, 1992, Vol.180, No.PtA, pp.555-557

Reflectometry Reveals Accumulation of Surfactant Impurities at Bare Oil/Water Interfaces
Ernesto Scoppola, Samantha Micciulla, Lucas Kuhrts, Armando Maestro, Richard A. Campbell, Oleg V. Konovalov, Giovanna Fragneto, Emanuel Schneck
Molecules 2019 24(22) 4113

Current Frontiers on Liquid-Liquid Interfaces Workshop
Yuri Gerelli, Richard Campbell, Giovanna Fragneto, Ernesto Scoppola, Fabio Comin, Oleg Konovalov, and Olivier Diat
Neutron News 2016, vol. 27, issue 1, 21-22

Progress in neutron reflectometry instrumentation
Giovanna Fragneto and Alain Menelle
Eur. Phys. J. Plus (2011) 126: 105

FIGARO: The new horizontal neutron reflectometer at the ILL (pdf - 6.07 Mi)
R.A. Campbell, H.P. Wacklin, I. Sutton, R. Cubitt, and G. Fragneto
Eur. Phys. J. Plus (2011) 126: 107

Réflectivité de neutrons : exemples d’études des systèmes en matière molle (pdf - 560 Ki)
G. Fragneto
Collection SFN 11 (2010) 89–100

Scientific Highlights from FIGARO’s first year (pdf - 347 Ki)
Richard A. Campbell, Hanna P. Wacklin, Robert Cubitt & Giovanna FragnetoNeutron News 2009

New sources and instrumentation for neutrons in biology (pdf - 347 Ki)
Teixeira SCM, Zaccai G, Ankner J, et al.
Chemical Physics, 2008, 345, 2-3, 133-151

REFILL2002. Advances in the study of interfaces with neutron reflection
Cubitt R., Fragneto G., Ghosh R.E., Rennie A.R. - Langmuir Vol. 19 pp. 7685-7687, 2003

D17: The new reflectometer at the ILL (pdf - 140 Ki)
Cubitt R., Fragneto G. - Applied Physics A Vol. 74 pp. S329-S331, 2002

Neutron reflection: Principles and examples of applications (pdf - 2.38 Mi)
Cubitt R., Fragneto G. -in SCATTERING - Eds. PIKE AND SABATIER, 2001

Guest editor Special Issue EPJE “Biological Physics Near Surfaces/Interfaces”, 2009, 30 (2)

James A. Forrest (Editor) , Department of Physics, University of Waterloo, Ontario, Canada
Giovanna Fragneto (Guest Editor), Institut Laue-Langevin, Grenoble, France
A Challenging Topic
Research on the structure and dynamics of biomolecules at surfaces and interfaces has boosted in recent years. Such work involves efforts from a variety of disciplines including physics.
As a reflection of the growing importance of this area, and especially the application of physical techniques (both experimental and theoretical) EPJ E is composing a special issue on the topic of Biological Physics at Surfaces and Interfaces.

Areas of interest include:

• Protein adsorption to surfaces (Biomaterials)
• Effect of surfaces on structure/function
•  Protein-nanoparticle interactions
• Cell adhesion/friction
• Lipid-protein interaction”

Please note:  The copyrights to these publications are held by their publishers.  The pdf files provided here are for personal use, only.  They may not be reposted on any other web site or used for any other purpose without the express permission of the appropriate publishers.

• Member of Advisory Board/Organizing Committee of following international conferences: ECNS2019, Biophee2019, ICNS2017, ISMC2016, ECOSS2016, ECIS2016, SXNS2016, ECIS2012,    ICNS9, JDN17, SXNS10, ECNS2007, SXNS9, IUCr2005, ICM2003
• Member of the organising committee of the HERCULES school since 2001
• 2017 - Member of ESS Scientific Advisory Board
• since 2011 member of the editorial board of the European Physical Journal E
• 2016 -  Member of Advisory Board of GEM (groupe d’étude sur les membranes)
• 2016 -  Member of D50 Scientific Advisory Committee
• 2016 -  Co-responsible area “Caractérisation et modélisation” GDR Bio-ingénierie des interfaces
• 2016-2018 Member of advisory board of ESS STAP on sa mple environment
• 2014-2016 Member of advisory board of ESS STAP on reflectometry
• 2015 – Member of SuperAdam board
• Editor (with F. Gabel) of EPJE Topical Issue “Neutron Biological Physics” appeared in July 2013
• Member of Proposal Review Panels at HZB, NIST and ANSTO.
• 2009 Member of Nature Reader Panel
• 2009 Guest Editor Special Issue of EPJE “Biological Physics near Surfaces/Interfaces” Vol 30, issue 2
• 2011 Guest editor EPJ Plus Focus Point “Neutron Reflectometers”
• 2011-2016 Member of SAC of Harwell Complex (UK)
• since 2011 Member of the CNR Commission on European Large Scale Facilities
• since 2008 Observer at ILL Scientific Council meetings
• 2011 Member of Jury de Thèse Societé Française Neutronique
• Member of Jury of several PhDs (in Belgium, Denmark, France, Italy, Sweden, UK)