Lukas Gajdos
Research Scientist | |
|---|---|
Office | 335 - Science Building - 3rd floor |
Phone | +33 (0) 4 76 20 72 54 |
Responsibilities
Research scientist and instrument co-responsible for the neutron macromolecular crystallography beamline LADI-DALI.
Science
During my PhD studies at the University Grenoble Alpes, I focused on studying carbohydrate-binding proteins from pathogenic bacteria using neutron and X-ray macromolecular crystallography. Perdeuteration of protein and carbohydrate molecules played an important role in studying these interactions using neutron diffraction and ILL offers unique expertise in deuteration of biomolecules.
I continue working on sugar binding proteins involved in bacterial infection but I am open to collaborate on different projects that can benefit from determination of hydrogen atom positions in protein structures.
Journal Publications
Gajdos, L., Blakeley, M.P., Haertlein, M., Forsyth, V.T., Devos, J.M., and Imberty, A. (2022). Neutron crystallography reveals mechanisms used by Pseudomonas aeruginosa for host-cell binding. Nat. Commun. 13, 194. doi: 10.1038/s41467-021-27871-8
Gajdos, L., Blakeley, M.P., Kumar, A., Wimmerová, M., Haertlein, M., Forsyth, V.T., Imberty, A., and Devos, J.M. (2021). Visualization of hydrogen atoms in a perdeuterated lectin-fucose complex reveals key details of protein-carbohydrate interactions. Structure 29, 1003–1013. doi: 10.1016/j.str.2021.03.003
Gajdos, L., Forsyth, V.T., Blakeley, M.P., Haertlein, M., Imberty, A., Samain, E., and Devos, J.M. (2021). Production of perdeuterated fucose from glyco-engineered bacteria. Glycobiology 31, 151–158. doi: 10.1093/glycob/cwaa059
Meldal, B.H.M., Bye-A-Jee, H., Gajdoš, L., Hammerová, Z., Horáčková, A., Melicher, F., Perfetto, L., Pokorný, D., Lopez, M.R., Türková, A., et al. (2018). Complex Portal 2018: extended content and enhanced visualization tools for macromolecular complexes. Nucleic Acids Res. 47, D550–D558. doi: 10.1093/nar/gky1001