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Health

Highlights

Although many diseases have been eradicated or brought under control in the past century or two, public health will always be a major societal challenge. Increased life expectancy has caused a surge in age-related conditions, chronic disease and disability, while developing countries still suffer the burden of HIV/AIDS, malaria and tuberculosis. As the COVID-19 pandemic has clearly demonstrated, it is extremely difficult to contain highly contagious diseases in our global mobile society. It is therefore vital that we prepare for future health challenges while continuing our efforts to address current health issues.

A thorough understanding of the complex biological processes that underlie health and disease is the key to progress in this field. Thanks to their unique properties, neutrons can provide precise information on hydrogen atoms and hydrogen bonding, knowledge that is crucial for understanding the biological function of enzymes and for improving drug efficiency, delivery and formulation. Pharmaceutical companies, like AstraZeneca, BioNTech and NUVISCAN, use neutrons at ILL as a part of their analytical toolbox.


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How neutrons help us understand the industrial production of therapeutic molecules

Staphylococcus Bacteria. Methicillin-resistant Staphylococcus aureus (MRSA)
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An interdisciplinary team of researchers has established a set of conditions under which sustainable fatty acid complexes can efficiently fight against dangerous, antibiotic-resistant bacteria. The results are encouraging and inspire further research…

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Antimicrobial peptides (AMPs) are natural antibiotics which are very effective against resistant bacteria. Despite their interesting properties, AMPs remain difficult to use. A study just published marks a remarkable step forward in understanding how…

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The goal of this study was to complete the mapping of the dynamics of the well-known protein Hsp90 by studying the 5-500 ns timescale using a combination of state-of-the-art complementary techniques, and to take the first steps towards understanding…

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An article recently published in Cell Reports reveals how researchers have for the first time directly visualized the position of protons within key functional elements of an enzyme that plays an important role in the metabolism of many…

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Understanding the interactions of biomolecules such as proteins or drugs with the membrane of cells is important in biomedical research and for the pharmaceutical industry. The sensitivity of neutrons to hydrogen atoms make neutron scattering a…

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Courtesy of Alison Oliver (STFC,RAL,ISIS)

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