Infos

L'Institut Laue-Langevin, partenaire de longue date de l'Université Grenoble Alpes (UGA) est fier de jouer un rôle clé dans le projet GATES (Grenoble ATtractivité et ExcellenceS). Ce programme ambitieux vise à développer des projets de recherche d'excellence et à renforcer l'attractivité de Grenoble en tant que pôle scientifique d'envergure internationale.

Le campus européen Photon et Neutron (EPN) de Grenoble est également un lieu unique pour la recherche en biologie structurale. Un article de synthèse sur les perspectives actuelles et futures de la biologie structurale sur le campus EPN vient de paraître dans le Journal of Synchrotron Radiation.

Un article récemment publié dans Cell Reports Physical Science révèle comment des chercheurs ont, pour la première fois, directement visualisé la position des atomes d'hydrogène dans les éléments fonctionnels clés d'une enzyme qui joue un rôle important dans le métabolisme de nombreux micro-organismes. Les mesures de diffraction neutroniques effectuées sur LADI III sur des cristaux de protéines perdeutérées produits dans des conditions de microgravité à la Station spatiale internationale (ISS) ont été les éléments clés de ce travail.

The worst of COVID-19 may have past, but new viral variants keep showing up. Developing new drugs that remain potent against the emerging variants is essential to stopping the spread of the deadly disease and protecting human health.After more than two years of studying SARS-CoV-2—the virus that c…

Pseudomonas aeruginosa is a human opportunistic pathogen that causes severe infections in immunocompromised patients. P. aeruginosa and other pathogenic bacteria use several virulence factors to promote their infectivity, including sugar-binding proteins.Teams of researchers at CERMAV (CNRS) and t…

Credit: Institut Laue-Langevin/ University of Leicester An international research team led by the University of Leicester has made a breakthrough advance by trapping an intermediate in the mechanism of enzymes called heme peroxidases and determining its structure u…

Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme will provide researchers and drug developers with significantly enhanced abilities to understand and treat fatal diseases and neurological disorders

The C-D loop in transthyretin is tight in the stable T119M mutant (protective against amyloidosis). However, the same loop at the mutation site of the S52P mutant (associated with the most aggressive form of transthyretin amyloidosis) is loosened, causing degradation of the protein and misfolding…

Key binding characteristics of a sugar-binding protein associated with heart disease and breast cancer defined for the first time, guiding future drug developmentResearchers pinpoint hydrogen-bonding interactions in the C-terminal carbohydrate recognition domain of galectin-3 (galectin-3C) for the first time using neutron crystallographyThese detailed observations will inform future drug design f…

A neutron diffraction pattern from a crystal of the PKG II enzyme binding domain with an activator bound, collected using the LADI-III beamline at the Institut Laue-Langevin. Credit:Blakeley & Kovalevsky. Enzyme associated with stomach cancer and osteoporosis s…