Quasi-Laue diffractometer

Perdeuterated crystals

Shown here is a perdeuterated crystal of HIV-1 Protease/amprenavir complex (vol = 0.2 mm3)used to collect data to 2.0 Å resolution using LADI-III.

Long-Range Electrostatics-Induced Two-Proton Transfer Captured by Neutron Crystallography in an Enzyme Catalytic Site. Gerlits O, Wymore T, Das A, Shen CH, Parks JM, Smith JC, Weiss KL, Keen DA, Blakeley MP, Louis JM, Langan P, Weber IT, Kovalevsky A. Angew Chem Int Ed Engl. (2016) 55(16), 4924-4927.

Joint X-ray/neutron crystallographic study of HIV-1 protease with clinical inhibitor amprenavir - insights for drug design. Weber IT, Waltman MJ, Mustyakimov M, Blakeley MP, Keen DA, Ghosh AK, Langan P, Kovalevsky AY. J. Medicinal Chemistry (2013) 56(13), 5631–5635.