21/10/2026 - 14h00 to 16h00
College 9 Seminar | Wound Healing – Redefining Fibrinogen Adsorption at the Air–Water Interface: an Intriguing Story with Multiple Layers
Presented by Richard CampbellLayer-by-layer self-assembled structures of the blood-clotting glycoprotein fibrinogen have been resolved at a fluid interface using neutron reflectometry and complementary techniques to reveal an unexpected mechanism that contradicts a long-established adsorption model. The widely accepted monolayer tilt model, inferred over two decades ago from ellipsometry data, involves progressive tilting of a monolayer of fibrinogen molecules from parallel with the interface with increasing interfacial coverage until, at saturation, the molecules adopt a more vertical confor…