07/09/2026 - 14h00 to 16h00
College 8 Seminar | Membrane interactions of the pore-forming α-synuclein oligomer
Seminar room 110-111, ILL 50, 1st floorZoom Linkhttps://ill.zoom.us/j/93819944809Meeting ID: 938 1994 4809Aggregates of the protein α-synuclein (αSyn) are widely regarded as the pathological hallmark of a group of neurogenerative diseases called synucleinopathies, which include Parkinson’s disease. In its monomeric form, αSyn performs a wide range of functions at nerve terminals, for which its ability to bind membranes is essential. In contrast, oligomers of αSyn are increasingly recognised as key toxic species in the pathogenesis of Parkinson’s disease, yet the structural basis of their memb…