May 12, 2023
Neutron scattering and selective deuteration reveal the structure and composition of mRNA-containing LNPs and the effects induced by the serum protein ApoE
The serum protein ApoE is known to bind to LNPs after administration and to be critical for cellular uptake and protein production in the liver. The acquisition of complementary SANS and SAXS data revealed the structural and compositional effects induced by this binding: a rearrangement of both t…