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May 12, 2023 Neutron scattering and selective deuteration reveal the structure and composition of mRNA-containing LNPs and the effects induced by the serum protein ApoE
The serum protein ApoE is known to bind to LNPs after administration and to be critical for cellular uptake and protein production in the liver. The acquisition of complementary SANS and SAXS data revealed the structural and compositional effects induced by this binding: a rearrangement of both t…
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April 6, 2022 Exploring the protein folding chaperones at the heart of our cells
Insulin is a hormone that is rapidly secreted into the blood, following a meal, in order to control blood glucose levels. These pulses of insulin secretion enable the body to take up and store sugar and quickly return blood glucose to normal levels. Diabetes, which affects 1 in 10 people in Europe, occurs when this process goes wrong.The endoplasmic reticulum (ER), a protein-producing compartment…