The rheological and structural properties of Fmoc peptide based hydrogels: The effect of aromatic molecular architecture on self-assembly and physical characteristics, E. Gazit, R. Orbach, I. Mironi-Harpaz, L. Adler-Abramovich, E. Mossou, E.P. Mitchell, V.T. Forsyth, D. Seliktar, Langmuir (in press).
Direct Determination of the Hydrogen Bonding Arrangement in Anhydrous β-chitin by Neutron Fiber Diffraction, D. Sawada, Y. Nishiyama, P. Langan, V.T. Forsyth, S. Kimura, M. Wada, Biomacromolecules (2012) 13, 288-291.
Structure and operation of the DNA-translocating Type I DNA restriction enzymes. C.K. Kennaway, J.E. Taylor, C.F. Song, W. Potrzebowski, W. Nicholson, J.H. White, A. Swiderska, A. Obarska-Kosinska, P. Callow, L.P. Cooper, G.A. Roberts, J.-B. Artero, J.M. Bujnicki, J. Trinick, G. Kneale, D.T.F. Dryden, Genes & Development (in press).
Nanostructure of cellulose microfibrils in spruce wood, A.N. Fernandes, L.M. Thomas, C.M. Altaner, P. Callow, V.T. Forsyth, D.C. Apperley, C.J. Kennedy & M.C. Jarvis, Proc. Natl. Acad. Sci. USA. (2011, in press).
Determination of the Base-Pair Force Constant of DNA from the Acoustic Phonon Dispersion of the Double Helix, L. Van Eijck, L., Merzel, F., Rols, S., Olivier, J., Forsyth, V.T., Johnson, M.R., Direct Phys. Rev. Lett. 107, 088102 (2011, in press). [Highlight in Nature 477, 372 (2011)]
Bilayer-mediated clustering and functional interaction of MscL channels. S.L. Grage, A.M. Keleshian, T. Turdzeladze, A.R. Battle, W.C. Tay, R.P. May, S.A. Holt, S.A. Contera, M. Haertlein, M. Moulin, P. Pal, P.R. Rohde, V.T. Forsyth, A. Watts, K.C. Huang, A.S. Ulrich, B. Martinac, Biophys J. 2011 Mar 2;100(5):1252-60.
Common architecture of nuclear receptor heterodimers on DNA direct repeat elements of different spacings. N. Rochel, F. Ciesielski, J. Godet, E. Moman, M. Roessle, C. Peluso-Iltis,M. Moulin, M. Haertlein, P. Callow, Y. Mély, D.I. Svergun, D. Moras, Nature Structural and Molecular Biology (2011), in press.
Using neutron protein crystallography to understand enzyme mechanism, J. Glusker, A. Kovalevsky, L. Hanson, Z. Fisher, M. Mustkakimov, S.A Mason, V.T. Forsyth, P. Langan, Acta Cryst. D (in press).
Neutron Macromolecular crystallography with LADI-III, M.P. Blakeley, S.C.M. Teixeira, Isabelle Petit-Haertlein, I. Hazemann, Andre Mitschler, M. Haertlein, E. Howard, A.D. Podjarny, Acta Cryst. D, (2010) 66 (11), 1198-1205.
Effect of crowding on the conformation of interwound DNA strands from neutron scattering
measurements and Monte Carlo simulations, Xiaoying Zhu, Siow Yee Ng, Amar Nath Gupta, Yuan Ping Feng, Bow Ho, Alain Lapp, Stefan U. Egelhaaf,
V. Trevor Forsyth, Michael Haertlein, Martine Moulin, Ralf Schweins, and Johan R. C. van der Maarel,
Phys. Rev. (2010) E 81, 061905
The Double Super Helix model of high density lipoprotein, Wu Z, Gogonea V, Lee X, Wagner MA, Li XM, Huang Y, Undurti A, May RP, Haertlein M, Moulin M, Gutsche I, Zaccai G, Didonato JA, Hazen SL. (2009)
J. Biol. Chem. (2009) 284(52):36605-19.
Matchout deuterium labelling of proteins for low resolution neutron scattering studies of biological macromolecules, P. Callow, J.-B. Artero, M. Weidenhaupt, M. Smolle, O. Byron, J. G. Lindsay, S.C.M. Teixeira, M. Moulin, M. Haertlein, V.T. Forsyth, E. Biophys. J. (in preparation).
Selective deuterium labelling of DNA polymers, I. Parrot, M. Haertlein, V.T. Forsyth, Eur. Biophys. J. (2008) 37 (6), 815-822
New sources and instrumentation for neutrons in biology, S.C.M. Teixeira, J.F. Ankner, M.C. Bellissant-Funel, R. Bewley, M.P. Blakeley, P. Callow, L. Coates, R. Dahint, R. Dagliesh, N. Dencher, J. Dhont, P. Fischer, T. Forsyth, G. Fragneto, B. Frick, J. Geue, R. Gilles, T. Gutberlet, M. Haertlein, T. Hauss, W. Häussler, W.T. Heller, K. Herwig, O. Holderer, F. Juranyi, R. Kampmann, R. Knott, J. Kohlbrecher, S. Kreuger, P. Langan, R. Lechner, G. Lynn, C. Majkrzak, R. May, F. Meilleur, Y. Mo, K. Mortensen, D.A.A. Myles, F. Natali, C. Neylon, N. Niimura, J. Ollivier, A. Ostermann, J. Peters, J. Pieper, A. Rühm, D. Schwahn, K. Shibata, A.K. Soper, T. Straessle, U.-i. Suzuki, I. Tanaka, M. Tehei, P. Timmins, N. Torikai, T. Unruh, V. Urban, R. Vavrin, K. Weiss, G. Zaccai, (2008). Chem. Phys. 345, 133-151.
Solvent isotope effect on macromolecular dynamics in E. coli, Jasnin M, Tehei M, Moulin M, Haertlein M, Zaccai G., (2008). Eur. Biophys. J. 37, 613-617.
X-ray and Neutron Small-Angle Scattering Analysis of the Complex Formed by the Met Receptor and the Listeria monocytogenes Invasion Protein InlB, Niemann HH, Petoukhov MV, Härtlein M, Moulin M, Gherardi E, Timmins P, Heinz DW, Svergun DI., (2008) J. Mol. Biol. 377, 489-500.
Coincidence of Dynamical Transitions in a Soluble Protein and Its Hydration Water: Direct Measurements by Neutron Scattering and MD Simulations, Wood K, Froelich A, Paciaroni A, Moulin M, Haertlein M, Zaccai G, Tobias GJ, Weik M, (2008). J. Am. Chem. Soc. 130, 4586-4587.
Down to atomic scale intracellular water dynamics, Jasnin M, Moulin M, Haertlein M, Zaccai G, Tehei M, (2008) EMBO Reports 9, 545-547.
NMR Crystallography: The effect of deuteration on high resolution 13C solid state NMR spectra of a 7-TM protein, K. Varga, L. Aslimovska, I.M. Parrot, M.-T. Dauvergne, M. Haertlein, V.T. Forsyth, A. Watts, Biochim. Biophys. Acta. 1768, 3029-3035 (2007). Adaptation to high temperatures through macromolecular dynamics by neutron scattering, Tehei, M., and Zaccai, G., (2007) FEBS Journal 274, 4034–4043.
Shape and subunit organisation of the DNA methyltransferase M.Ahdl, Callow, P., Sukhodub, A., Taylor, J., Kneale, G., J. Mol. Biol. 69, 177-185 (2007). A methodology and an instrument for the temperature-controlled optimization of crystal growth, Budayova-Spano, M. , Dauvergne,F., Audiffren, M., Bactivelane, T., Cusack, S., (2007) Acta Cryst. D63, 339–347.
Neutron scattering reveals extremely slow cell water in a Dead Sea organism. M. Tehei, B. Franzetti, K. Wood, F. Gabel, E. Fabiani, M. Jasnin, M. Zamponi, D. Oesterhelt, G. Zaccai, M. Ginzburg and B.-Z. Ginzburg (2007). PNAS, 104(3), 687-1104.
A methodology and an instrument for the temperature-controlled optimization of crystal growth. M. Budayova-Spano, F. Dauvergne, M. Audiffren, T. Bactivelane and S. Cusack. (2007). Acta Cryst. D63, 3, 339-347.
The effect of deuteration on protein structure: a high-resolution comparison of hydrogenous and perdeuterated haloalkane dehalogenase. X. Liu, B. L. Hanson, P. Langan and R.E.Viola (2007). Acta Cryst. D63, 1000-1008.
Expression, purification, assay, and crystal structure of perdeuterated human arginase I. Di Costanzo, L., Moulin, M., Haertlein, M., Meilleur, F., Christianson, D.W (2007). Arch. Biochem. Biophys. 465(1), 82-89.
Adaptation to high temperatures through macromolecular dynamics by neutron scattering, Tehei, M., and Zaccai, G. (2007). FEBS Journal 274, 4034–4043.
Shape and subunit organisation of the DNA methyltransferase M.Ahdl, Callow, P., Sukhodub, A., Taylor, J., Kneale, G., (2007). J.Mol. Biol. 69 (1), 177-185.
Neutron scattering reveals extremely slow cell water in Dead Sea organisms, Tehei, M., Franzetti, B., Wood, K., Gabel, F., Fabiani, E., Jasnin, M., Zamponi, M., Oesterhelt, D., Zaccai, G., Ginzburg, M., Ginzburg, B.-Z. (2007). Proc. Nat. Acad. Sci 104 (3), 766-771.
Structural studies on acridine derivatives binding to telomeric DNA. Miles, S., Callow, P., Teixeira, S.C.T., Gan, Y., Denny, W., Cardin, C., Forsyth, V.T. (2006). Physica B 845, 385-386.
Efficient characterization of protein secondary structure in terms of screw motions, G.Kneller, P.Calligari (2006). Acta Cryst D62, 302-311.
A preliminary neutron diffraction study of Rasburicase, recombinant urate oxidase enzyme, complexed with 8-azaxanthin. Budayova-Spano M., Bonneté F., Ferté N., El Hajji M., Meilleur F., Blakeley M., Castro B. (2006). Acta Cryst. F62, 306-309.
High-Angle Neutron Fibre Diffraction in the Study of Biological systems.Forsyth, V.T., and Parrot, I.M. (2006). Neutron Scattering in Biology - Techniques and Applications, Springer Series on Biological and Medical Physics/Biomedical Engineering, Eds Fitter, J., Gutberlet, T., Katsaras, J.
Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II. Budayova-Spano, M., Zoe Fisher, S., Dauvergne, M.-T., Agbandje-McKenna, M., Silverman, D.N., Myles, D., McKenna, R. (2006). Acta Cryst. F62, 4-9.
Discovering New Classes of Brugia malayi Asparaginyl tRNA Synthetase Inhibitors and Relating Specificity to Conformational Change. S. C. K. Sukuru, T. Crepin, Y. Milev, L. C. Marsh, J. B. Hill, R. J. Anderson, J. C. Morris, A. Rohatgi, G. O'Mahony, M. Grotli, F. Danel, Y. Milev, M. G. P. Page, M. Hartlein, S. Cusack, M. A. Kron, and L. A. Kuhn. (2006). J. Comp.-Aided Mol. Design 20(3): 159-178 (DOI 10.1007/s10822-006-9043-5).
Brugia malayi asparaginyl-Transfer RNA synthetase Induces Chemotaxis of human leucocytes and activates G-protein-coupled receptors CXCR1 and CXCR2. Ramirez, B.L., Howard, O.M., Dong, H.F., Edamatsu, T., Gao, P., Haertlein, M., Kron, M. (2006). J. Infec. Dis. 193 (8), 1164-71.
X-rays and neutrons for the study of DNA structure, transitions and hydration. Parrot, I.M., Laux, V., Urban, V., Haertlein, M., Forsyth, V.T. (2006). Physica B 848, 385-386.
Neutrons in biology: Institut Laue - Langevin, 4-7 September 2005, Deme B, Forsyth T, Fragneto G, Hartlein M, May R, Timmins P, Zaccai G., Eur Biophys J. (2006), 35(7):549-50.
Production and X-ray crystallographic analysis of fully deuterated cytochrome P450cam. Meilleur F, Dauvergne MT, Schlichting I, Myles D.A. (2005). Acta Cryst. D61(5), 539-44.
Protonation states in human aldose reductase observed with high resolution X-ray crystallography and preliminary neutron diffraction results, Blakeley M., Hazemann, I. Mitschler, A., Meilleur, F., Dauvergne, Haertlein, M, El-Kabbani, O., Cousido, A., van Zandt, M., Oka, M., Joachimiak, A., Petrova, T., Myles, D.A.A.,Podjarni, A.D.,
Chapter 2, Neutron Crystallography, 87-102, In Hydrogen- and Hydration-Sensitive Structural Biology, Eds. Nimura, N. Mizuno, H., Helliwell, J.R.and Westhof, E.
High-resolution neutron protein crystallography with radically small crystal volumes: application of perdeuteration to human aldose reductase. Hazemann I, Dauvergne MT,Blakeley MP, Meilleur F, Haertlein M, Van Dorsselaer A, Mitschler A, Myles D.A., Podjarny A. (2005). Acta Cryst. D61, 10, 1413-7.
Real time characterization of intermediates in the pathway to open complex formation by RNA polymerase. Sclavi, B., Zaychikov, E., Rogozina, A., Walther, F., Buckle, M.,Heumann, H. (2005). PNAS 102, 4706-4711.
Effects of soman inhibition and of structural differences on cholinesterase molecular dynamics: a neutron scattering study. Gabel, F., Weik, M., Masson, P., Renault, F., Fournier, D., Brochier, L., Doctor, B., Saxena, A., Silman, I. & Zaccai, G. (2005). Biophys J. 89(5), 3303-11.
Liquid-like water confined in stacks of biological membranes at 200 k and its relation to protein dynamics. Weik, M., Lehnert, U. & Zaccai, G. (2005). Biophys J., Biophys J. 89(5), 3639-46.
Etudes par diffraction de fibres de l’ADN double brin. Forsyth, V.T. and Parrot, I.M. (2005). Journal de Physique IV, 130, 63-74.
Combined X-ray and Neutron Fibre Diffraction Studies of Biological and Synthetic Polymers. Parrot, I.M., Urban, V., Gardner, K.H., Forsyth, V.T.(2005). Nucl. Instr. Meth. in Phys. Res., B238, 7-15.
Neutron scattering reveals the dynamic basis of protein adaptation to extreme temperature. Tehei, M., Madern, D., Franzetti, B., Zaccai, G. (2005). J Biol Chem. 9, 280(49), 40974-9.
A comparison of refined X-ray structures of hydrogenated and perdeuterated ray gamma E crystallin in H2O and D2O. Artero, J.B., Hartlein, M., McSweeny, S., Timmins, P.A. (2005). Acta Cryst. D61, 1541-1549.
Do tissue levels of autoantigenic aminoacyl-tRNA synthetase predict clinical disease? Kron, M.A., Petridis, M., Haertlein, M., Libranda-Ramirez, B., Scaffidi, L.E. (2005). Med Hypotheses, 65(6), 1124-7.
Aminoacyl-tRNA Synthetases and Disease in the Aminoacyl-tRNA
synthetases,
Kron M, Härtlein M. Landes Biosciences Publishers. Eds: Michael Ibba, Christopher Franklyn and Stephen Cusack. (2005)
Water-DNA interactions by x-ray and neutron fibre diffraction. Fuller, W., Forsyth, V.T., Mahendrasingam, A. (2004). Phil. Trans. Roy. Soc. 359, 1448, 1237-1248.
Structural stability and dynamics of hydrogenated and perdeuterated cytochrome P450cam (CYP101). Meilleur F, Contzen J, Myles DA, Jung C. (2004). Biochemistry 13, 8744-53.
Expression, Localization and Alternative Function of asparaginyl-tRNA synthetase
in Brugia malayi. M. Kron, M. Petridis, Y. Milev, J Leykam, M Härtlein. (2003), Molecular and Biochemical Parasitology, 129 (1), 33-39
Strategies for antifilarial drug development,
Kron M, Kuhn L, Sanschagrin , P.C., M Härtlein, Grotli M and Cusack S. (2003),
J Parasitology 89(Suppl.) S226-S235
