General ILL Seminar organised by College IX

Thursday, May 16, 2013, 9h30
Conference room 1st Floor, ILL 4

Dr. Evgenyi Shalaev

Allergan Inc, RD2-2D, 2525 Dupont Drive, Irvine, CA 92612, USA

Pharmaceutical and biotech products represent systems of variable complexity, ranging from relatively simple molecules (e.g., aspirin) to biopolymers (e.g., proteins and olygonucleotides), viruses, and cell (e.g., parasite vaccines).  Use of synchrotron X-ray in characterization of pharmaceutically-relevant materials is on the rise, covering both simple aqueous solutions, amorphous solids, and multi-component and multiphase systems such as tablets.  Whereas neutron scattering, which is recognized as a powerful tool in studies of structure and dynamics of both proteins and small molecules, is still an exotic method for pharmaceutical R&D community.  The presentation provides examples of use of synchrotron X-ray scattering to solve issues encountered during development process, such as investigating physical stability of freeze-dried powders, evaluating crystalline mesophases in active ingredient and formulations, and monitoring amorphous and crystalline forms of an API in tablets.  Use of small-angle and wide-angle neutron scattering to probe heterogeneities in model aqueous solutions and glasses is discussed in some detail.  Potential future applications of neutron scattering, such as investigation of protein aggregation and predicting physical stability of pharmaceutical glasses, are highlighted.

Richard Campbell
College IX Secretary

External visitors may ask for a site access to Laurence Tellier (tellier@ill.fr)

General ILL Seminar organized by College 3

Tuesday, 21st May 2013, 11:00

Seminar room ILL1

H. Faust

ILL

 The spectroscopy of the prompt gamma decay from fission products gives information on the entry states, e.g. distribution functions for excitation energy and spin, and therefore a direct link to the fission process itself. This type of spectroscopy is, however, only possible when a filter can be constructed which allows to set a gate to the gamma- spectrum on a narrow region in mass and nuclear charge, as well as on part of the total excitation energy of the fragment split under investigation. A possible configuration of a prompt gamma-ray spectrometer consist of an gamma-ray array composed of high resolution germanium detectors, coupled to a gas filled magnet. In the presentation we will outline the principles for a gas filled magnetic spectrometer for fission product spectroscopy. In particular the focusing characteristics of such a device, which are valid for particles in the velocity regime of E/A<1MeV/amu, will be addressed. First experiments on the Lohengrin spectrometer in Grenoble investigating on the behaviour of fission products in gas filled magnets have been performed, and have validated the experimental approach to the nuclear fission process with such a device.