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Quasi-Laue diffractometer LADI-IV

The Laue diffractometer LADI-IV is mainly used for single-crystal studies of macromolecules at high resolution (1.5 - 2.5 Å) in order to locate individual protons or deuterons of special interest, water structures or other small molecules that can be marked with deuterium to be particularly visible. The complexity of systems that can be studied can reach about 150 Å on cell edge and the sample volumes required can be as low as 0.1-0.2 mm3.

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Instrument layout

A quasi-Laue diffractometer for biology

LADI-IV is a quasi-Laue diffractometer mainly used for single-crystal studies of small protein systems at medium or high resolution in order to locate individual hydrogen atoms of special interest, water structures or other small molecules that can be marked with deuterium to be particularly visible. The complexity of systems that can be studied can reach about 150 Å on cell edge and the sample volumes required can be as low as 0.1-0.2 mm3.

Applications

Neutron protein crystallographic projects aim to address questions concerning:

  • enzymatic mechanism
  • ligand-binding interactions
  • solvent effects
  • structure dynamics and their implications

Instrument layout

LADI IV is installed at the end of a cold neutron guide tube.